| Yazarlar (6) |
Ahmet Turk
Adıyaman Üniversitesi, Türkiye |
|
Busra Zencirci
Adıyaman Üniversitesi, Türkiye |
|
Tuba Ozcan-Metin
Adıyaman Üniversitesi, Türkiye |
|
Ibrahim Bozgeyik
Adıyaman Üniversitesi, Türkiye |
|
Abdullah Karadag
Adıyaman Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Seda KOÇAK
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Kisspeptin--1 (KISS--1) and Spexin (SPX) are neuropeptides that play crucial roles in metabolism and sexual function, with their expression levels in tissues potentially influenced by antioxidant treatments. This study aimed to investigate the effects of cortexin treatment against ischemia--reperfusion injury (I/R) resulting from testicular torsion on KISS--1 and SPX levels in testicular tissues. Twenty--eight male Sprague--Dawley, rats, aged 8--10 weeks, were divided into four equal groups: control, torsion, torsion/detorsion, and torsion/detorsion+ cortexin. At the conclusion of the experiment, histopathological and immunohistochemical analyses were performed to assess the expressions of KISS--1, SPX, tumor necrosis factor--alpha (TNF--α), and Caspase--3 in the testicular tissues. For biochemical analyses, total antioxidant status (TAS) and total oxidant status (TOS) levels were measured in serum samples using the ELISA method, while malondialdehyde (MDA) levels were assessed spectrophotometrically in testicular tissues. The results showed that compared to the control group, the torsion and torsion/detorsion groups exhibited significant histopathological damage, along with increased levels of MDA, TOS, Caspase--3, and TNF--α, and decreased levels of TAS, KISS--1, and SPX in the testicular tissues. Conversely, in the torsion+ detorsion+ cortexin group, which received treatment for reperfusion injury, there was a notable reduction in tissue damage, with decreased levels of MDA, TOS, caspase--3, and TNF--α, alongside increased levels of TAS, KISS, and SPX. Cortexin decreases testicular damage by reducing oxidative stress, increases ... |
| Anahtar Kelimeler |
| Kisspeptin-1 | Spexin | Testicular damage | Torsion | Detorsion |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS |
| Dergi ISSN | 0798-2259 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | 0798-2259 |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2025 |
| Cilt No | 35 |
| Sayı | 2 |
| DOI Numarası | 10.52973/rcfcv-e35554 |
| Atıf Sayıları |
