| Yazarlar (6) |
Dr. Öğr. Üyesi Selcen DURAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Asuman Çelikbilek
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Ahmet Said Çil
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Doç. Dr. Bilal İLANBEY
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Aydan KÖYSÜREN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Burç Esra ŞAHİN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Background Multiple sclerosis (MS) is an immune-mediated neuroinflammatory disorder with a multifactorial etiology involving genetic susceptibility, environmental triggers, and vascular contributions. Carotid intima–media thickness (CIMT) is a significant marker of endothelial dysfunction. Endothelial cell-specific molecule-1 (endocan) and hyaluronic acid, key components implicated in endothelial and vascular remodeling, may significantly contribute to the inflammatory and vascular pathologies observed in MS. We aimed to investigate the relationship between CIMT and endothelial biomarkers, such as endocan and hyaluronic acid, in patients with MS. Methods In this cross-sectional study, 100 patients with relapsing–remitting MS and 56 healthy controls were included. Demographic, clinical, laboratory, and imaging data were documented. CIMT was measured bilaterally using high-resolution B-mode ultrasonography. Serum endocan and hyaluronic acid levels were quantified via enzyme-linked immunosorbent assays. Results MS patients exhibited significantly higher CIMT and serum endocan levels compared with controls (p < 0.001). CIMT values were significantly elevated in MS patients, with longer disease duration, higher expanded disability status scale scores, and an older diagnosis age (p < 0.05). However, serum endocan and hyaluronic acid levels did not significantly differ between MS subgroups based on disease duration, disability severity, and diagnosis age. Additionally, there was no correlation between CIMT and serum endocan and hyaluronic acid levels in MS patients (p > 0.05). Conclusions Increased CIMT and serum … |
| Anahtar Kelimeler |
| endothelial dysfunction | carotid intima-media thickness | multiple sclerosis | endocan | hyaluronic acid | vascular pathology |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Life - Basel |
| Dergi ISSN | 2075-1729 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2025 |
| Cilt No | 15 |
| Sayı | 9 |
| Sayfalar | 1 / 13 |
| Doi Numarası | 10.3390/life15091388 |
| Makale Linki | https://doi.org/10.3390/life15091388 |
| Atıf Sayıları |
