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Akademisyenler > Murat MISIR > Yayın Detayı

Synthesis and Characterization of Py(PCL), Py(PLLA) Homopolymers and Py(PCL-b-PLLA) Copolymer via Ring-Opening Polymerization: Determination of Structural, Optical, and Biocompatible Properties  
Yazarlar (7)
Doç. Dr. Murat MISIR Doç. Dr. Murat MISIR
Kırşehir Ahi Evran Üniversitesi, Türkiye
Saliha Mutlu
Karadeniz Technical University, Turkey
Servin Bagheralmoosavi
Bilkent Üniversitesi, Turkey
Bülend Ortaç
Bilkent Üniversitesi, Turkey
Ali Karatutlu
Bilkent Üniversitesi, Turkey
Gurkan Yesilöz
Bilkent Üniversitesi, Turkey
Sevil Savaskan Yılmaz
Karadeniz Technical University, Turkey
Devamını Göster
Özet
Pyrene-functionalized poly(ɛ-caprolactone) (Py(PCL)), poly(L-lactide) (Py(PLLA)) homopolymers, and an AB-type block copolymer (Py(PCL-b-PLLA)) are synthesized via ring-opening polymerization (ROP) using Sn(Oct)2 catalyst with ɛ-CL and L-LA monomers. Structural characterization is confirmed by FTIR, 1H NMR, and XRD analyses, while thermal and optical properties are assessed using TGA, DSC, UV–vis, and photoluminescence spectroscopy. The polymers exhibited strong photoluminescence across 380–700 nm, high thermal stability, and nanostructured surface morphology as revealed by SEM and 3D laser microscopy. Biocompatibility is evaluated by culturing MCF-7 breast cancer cells on polymer-coated glass slides. The materials supported uniform cell distribution, robust adhesion, and sustained viability and proliferation. These results highlight the polymers’ suitability for tissue engineering and biomaterials research. The incorporation of pyrene units enabled intrinsic fluorescence tracking, positioning these polymers as multifunctional platforms for applications in cancer research, real-time bioimaging, and regenerative medicine. By combining fluorescence capability with biodegradability and promotion of cell growth, Py(PCL), Py(PLLA), and Py(PCL-b-PLLA) offer a promising, environmentally friendly approach bridging imaging and therapeutic delivery needs in biomedical applications.
Anahtar Kelimeler
AB-type diblock copolymer | MCF-7 breast cancer cells | Optic properties | Ring Opening Polymerization
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı Advanced Materials Interfaces
Dergi ISSN 2196-7350 Wos Dergi Scopus Dergi
Dergi Grubu Q2
Makale Dili İngilizce
Basım Tarihi 01-2025
Sayı 1
Doi Numarası 10.1002/admi.202500195
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Synthesis and Characterization of Py(PCL), Py(PLLA) Homopolymers and Py(PCL-b-PLLA) Copolymer via Ring-Opening Polymerization: Determination of Structural, Optical, and Biocompatible Properties

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