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Effect of CYP2C19*17 gene polymorphism on plasma levels of diazepam and nordiazepam in Turkish patients with Alcohol Withdrawal Syndrome   
Yazarlar (9)
Doç. Dr. Selin ÖZKAN KOTİLOĞLU Doç. Dr. Selin ÖZKAN KOTİLOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye
Dilek Akyüzlü
Ankara Üniversitesi, Türkiye
Mukaddes Asena Yıldırım
Mustafa Danışman
H. Ceren Bozmaoğlu
Kenan Can Tok
Ankara Üniversitesi, Türkiye
Mehmet Gümüştaş
Ankara Üniversitesi, Türkiye
İnci İlhan
Ankara Üniversitesi, Türkiye
Halit Sinan Süzen
Ankara Üniversitesi, Türkiye
Devamını Göster
Özet
IntroductionAlcohol withdrawal syndrome (AWS) is not a common medical condition in general population however it affects patients with alcohol use disorder (AUD) and causes severe complications when diagnosed late or left untreated. Diazepam is a benzodiazepine, which is used to treat various diseases such as insomnia, anxiety, muscle spasm, pain and AWS. Compared to other benzodiazepines, diazepam is more efficient to prevent delirium and decrease withdrawal due to its long half-life. Diazepam is metabolised to its main metabolite nordiazepam with the enzymes expressed by CYP2C19 and CYP3A4 genes. It has been reported that metabolic activity of the enzymes encoded by CYP2C19 gene may be varied due to genetic polymorphisms leading a change in the efficiency of treatment via effecting the plasma level of drugs metabolised by CYP2C19.ObjectivesThe aim of this study is to investigate …
Anahtar Kelimeler
Bildiri Türü Tebliğ/Bildiri
Bildiri Alt Türü Özet Metin Olarak Yayınlanan Tebliğ (Uluslararası Kongre/Sempozyum)
Bildiri Niteliği Alanında Hakemli Uluslararası Kongre/Sempozyum
Bildiri Dili İngilizce
Kongre Adı 33rdEUROPEAN CONGRESS OF PSYCHIATRY
Kongre Tarihi 05-04-2025 / 08-04-2025
Basıldığı Ülke İspanya
Basıldığı Şehir Madrid