| Yazarlar (7) |
Cengiz Guven
Adıyaman Üniversitesi, Türkiye |
|
Ahmet Turk
Adıyaman Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Seda KOÇAK
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Busra Zencirci
Adıyaman Üniversitesi, Türkiye |
|
Alper Yalcin
Kahramanmaraş Sütçü İmam Üniversitesi, Türkiye |
|
Hasan Aydin
Adıyaman Üniversitesi, Türkiye |
|
Mevlut Dogukan
Adıyaman Üniversitesi, Türkiye |
| Özet |
| ObjectiveBiomarkers such as Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor κ-B (RANK), its ligand RANKL, and Transient Receptor Potential Canonical 1 (TRPC1) have been implicated in the neuroprotective response to neuronal injury, with their expression potentially influenced by antioxidant treatments. The objective of this study was to investigate the effects of Cortexin on the expression of these biomarkers in brain tissue following cerebral ischemia-reperfusion (I/R) injury.MethodsThirty-five male Wistar albino rats were divided into five groups: control, ischemia (45 minutes), I/R (7 days), I/R + 1 mg/kg Cortexin, and I/R + 2 mg/kg Cortexin. On day 8, rats were euthanized, and brain and serum samples were collected. Immunohistochemical staining was used to assess biomarker expression in brain tissue, while serum total oxidant status (TOS) and total antioxidant status (TAS) were ... |
| Anahtar Kelimeler |
| OPG | RANK | RANKL | TRPC1 | cerebral ischemia |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı |
Neurological Research
|
| Dergi ISSN | 0161-6412 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2025 |
| Sayfalar | 1 / 12 |
| Doi Numarası | 10.1080/01616412.2025.2536075 |
| Makale Linki | https://doi.org/10.1080/01616412.2025.2536075 |
| Atıf Sayıları |
