| Yazarlar (7) |
Cengiz Guven
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Ahmet Türk
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Seda Koçak
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Busra Zencirci
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Alper Yalcin
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Hasan Aydın
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Mevlut Doğukan
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| Özet |
| ObjectiveBiomarkers such as Osteoprotegerin (OPG), Receptor Activator of Nuclear Factor κ-B (RANK), its ligand RANKL, and Transient Receptor Potential Canonical 1 (TRPC1) have been implicated in the neuroprotective response to neuronal injury, with their expression potentially influenced by antioxidant treatments. The objective of this study was to investigate the effects of Cortexin on the expression of these biomarkers in brain tissue following cerebral ischemia-reperfusion (I/R) injury.MethodsThirty-five male Wistar albino rats were divided into five groups: control, ischemia (45 minutes), I/R (7 days), I/R + 1 mg/kg Cortexin, and I/R + 2 mg/kg Cortexin. On day 8, rats were euthanized, and brain and serum samples were collected. Immunohistochemical staining was used to assess biomarker expression in brain tissue, while serum total oxidant status (TOS) and total antioxidant status (TAS) were ... |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale |
| Dergi Adı | Neurological Research |
| Dergi Tarandığı Indeksler | |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2025 |
| Sayfalar | 1 / 12 |
| Doi Numarası | 10.1080/01616412.2025.2536075 |
| Makale Linki | https://doi.org/10.1080/01616412.2025.2536075 |
| Atıf Sayıları |
