| Yazarlar (5) |
Hasan Caliskan
Balıkesir Üniversitesi, Türkiye |
|
Koray Hamza Cihan
Ankara Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Seda KOÇAK
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Gozde Karabulut
Kütahya Universitesi, Türkiye |
|
Erhan Nalcaci
Ankara Üniversitesi, Türkiye |
| Özet |
| Hypoxia can adversely affect multiple organ systems. This study investigated the impact of intermittent hypoxia on serotonin levels and depression-like behaviors across distinct neuroanatomical regions. Sixteen adult female Wistar albino rats were divided into two groups: control (n = 8) and hypoxia (n = 8). The hypoxia group was exposed to a simulated altitude of 3000 for 5 h daily over 14 days. Behavioral assessments included locomotor activity (open field test) and depression-like behaviors (forced swimming test). Serotonin levels were quantified via ELISA in the prefrontal cortex, striatum, thalamus, hypothalamus, hippocampus, and serum. Intermittent hypoxia did not alter locomotor activity (p > 0.05) but significantly increased depression-like behavior (p < 0.05), accompanied by a pronounced reduction in swimming behavior (p < 0.0001), a marker associated with serotonergic function. Serotonin levels were significantly reduced in the prefrontal cortex (p < 0.005) and striatum (p < 0.05), while no changes were observed in other regions or serum (p > 0.05). These findings demonstrate that intermittent hypoxia induces depression-like behaviors and region-specific serotonin depletion, particularly in the prefrontal cortex and striatum. This underscores the need to evaluate hypoxia-related brain health implications in conditions such as sleep apnea and acute mountain sickness. |
| Anahtar Kelimeler |
| depression-like behaviors | forced swimming test | hypoxia | prefrontal cortex | serotonin | striatum |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı |
Biology
|
| Dergi Tarandığı Indeksler | |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2025 |
| Cilt No | 14 |
| Sayı | 8 |
| Sayfalar | 931 / 0 |
| Doi Numarası | 10.3390/biology14080931 |
| Atıf Sayıları |
