| Yazarlar (1) |
Sevinc Alkan
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| Özet |
| Sarcopenia, the loss of muscle mass and strength that occurs with aging, has a crucial role in development of frailty. Sarcopenia is recognized as one of the major public health problems affecting approximately 8-40% of individuals greater than age 60 years worldwide. Although sarcopenia and other muscle-related traits are heritable, the underlying genetic variation contributing to the development of sarcopenia is unclear. Previously, researchers identified 18 genes that will delay the onset of sarcopenia in an animal model for aging, Caenorhabditis elegans (Kashyap, 2010), of which 14 have a human homolog and SNP genotypes that were assayed in individuals from the Health, Aging, and Body Composition Study (Health ABC). The primary aim of this study is to assess whether there is a relationship between >700 single nucleotide polymorphisms (SNPs) total in 27 genes [14 genes identified from C. elegans and 13 genes in the mevalonate and ubiquinone pathways] and six traits related to sarcopenia using data from the HealthABC cohort. The 6 outcome variables are isokinetic leg muscle maximum torque( KCTMAX), thigh muscle density(THMUSD), thigh intermuscular fat area(THIMF), total lean mass (TOTLEAN), total percent fat(TOTPF) and thigh total muscle area(THMUS). The European and African American cohort were analyzed separately. After adjusting for the effects of gender, age, and ancestry, single SNP: single trait association tests were performed. Although no SNPs were statistically significant at the experiment-wide p-value (p< 0.00001), SNPs in the locus MAGOHB were associated with THIMF, THMUSD, and TOTPF in ... |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Uluslararası alan indekslerindeki dergilerde yayımlanan tam makale |
| Dergi Adı | Journal of Biology, Agriculture and Healthcare |
| Dergi Tarandığı Indeksler | |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2012 |
