| Yazarlar (6) |
Dr. Öğr. Üyesi Ferhat PEKTAŞ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Nurcan Dursun
Türkiye |
|
Burak Tan
Türkiye |
|
Oğuzhan Yaylalı
Türkiye |
|
Ercan Babur
Türkiye |
|
Cem Süer
Türkiye |
| Özet |
| Thyroid hormone dysfunction may affect intracellular signaling cascades and have a role in regulating cognitive function, particularly in brain areas associated with learning and memory. The study aims to show the effect of curcumin supplementation on long-term potentiation (LTP) under conditions of hypothyroidism and to elucidate changes in the pathways thought to play a key role in cognitive dysfunctions associated with hypothyroidism. Hypothyroidism was induced by administering propylthiouracil (PTU; 0.05%) through drinking water and curcumin was intraperitoneally (Ip) administered through daily injection (70 mg/kg/day). The slope of field excitatory-postsynaptic potential (fEPSP) and population spike (PS) were evaluated by applying high-frequency stimulation (HFS) in the hippocampal dentate gyrus (DG). Total and phosphorylated tau, kinases and phosphatases in the whole hippocampus were … |
| Anahtar Kelimeler |
| long-term potentiation | hypothyroidism | curcumin | GSK3 beta/PP2A | tau |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Neurochemical Journal |
| Dergi ISSN | 1819-7124 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2025 |
| Cilt No | 19 |
| Sayı | 1 |
| Sayfalar | 81 / 91 |
| Doi Numarası | 10.1134/S1819712425700102 |
| Makale Linki | https://doi.org/10.1134/s1819712425700102 |
| Atıf Sayıları |
