Royal jelly alleviates gemcitabine-induced ovarian toxicity: an investigation on rat models
Yazarlar (7)
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Betül Yalçın
Adiyaman University, Türkiye
Adiyaman University, Türkiye
Dr. Öğr. Üyesi Halime TOZAK YILDIZ Kırşehir Ahi Evran Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ertan KATIRCI Kırşehir Ahi Evran Üniversitesi, Türkiye
Eda Okur Türkiye
Demet Bolat
Erciyes University, Türkiye
Erciyes University, Türkiye
Arzu Hanım Yay Erciyes Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BMC COMPLEMENTARY MEDICINE AND THERAPIES (Q1) | ||
| Dergi ISSN | 2662-7671 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 25 / 1 / 1–16 | DOI | 10.1186/s12906-025-05013-7 |
| Makale Linki | https://doi.org/10.1186/s12906-025-05013-7 | ||
| Özet |
| BackgroundRoyal Jelly (RJ), an important product of apitherapy, has been traditionally used for its various health benefits, particularly for its anti-inflammatory, antioxidant, and immune-modulatory properties. RJ’s ability to reduce oxidative stress, inflammation, and cellular damage has made it a promising candidate for preserving ovarian function and fertility during cancer treatments. Gemcitabine (GEM) is an antimetabolite chemotherapeutic drug known to cause ovarian toxicity. To date, there has been no study evaluating the protective effects of RJ specifically against GEM-induced ovarian damage, making this an original contribution to the field. This study investigated RJ’s protective effects against GEM-induced ovarian toxicity in rats.MethodThirty-two female Wistar-Albino rats were divided into four groups: Control, RJ, GEM, and GEM + RJ. GEM (200 mg/kg) was administered intraperitoneally, while RJ (100 … |
| Anahtar Kelimeler |
| Gemcitabine | Royal jelly | Apitherapy | Ovary | Inflammation | Oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |
| Web of Science | 2 |