Effects of 3-Bromo-2-oxopropionic acid and LiCl treatment combined with electroporation on apoptotic and metabolic responses in DLD-1 colon cancer cells
Yazarlar (2)
Dr. Öğr. Üyesi Güney GÜRSOY Kırşehir Ahi Evran Üniversitesi, Türkiye
Zehra Çiçek Sağlık Bilimleri Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Medical Oncology (Q2) | ||
| Dergi ISSN | 1357-0560 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 42 / 8 / 326–0 | DOI | 10.1007/s12032-025-02898-9 |
| Makale Linki | https://doi.org/10.1007/s12032-025-02898-9 | ||
| Özet |
| Colon cancer is particularly increasing in incidence in developed countries, and it ranks first in terms of morbidity and mortality worldwide. As in other types of cancer, metabolic changes and cellular death mechanisms play a critical role in cancer treatment. Cancer cells prefer glycolysis for energy production even in the presence of oxygen; this phenomenon is known as the Warburg effect. Glycolysis, which is essentially an anaerobic process, provides metabolic adaptation by preventing mitochondrial oxidative phosphorylation in cancer cells. Electroporation (EP) is a method that increases the uptake of drugs into the cell by creating temporary pores in the cell membrane. 3-Bromo-2-oxopropionic acid and Lithium chloride (LiCl) are agents that may show anticancer potential through different mechanisms. The aim of this study was to investigate the potential anticancer effects of the EP-assisted combination of 3 … |
| Anahtar Kelimeler |
| Electroporation | 3-Bromo-2-oxopropionic acid | Lithium chloride | Caspase-3 activity | Metabolic markers | Anticancer treatment strategies |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |