Pharmacoepigenetics in schizophrenia: Predicting drug response
Yazarlar (5)
Arş. Gör. Aybüke Yıldırım Türkiye
Irmak Dal Ankara University
Doç. Dr. Selin ÖZKAN KOTİLOĞLU Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Bora Baskak Ankara Üniversitesi, Türkiye
Prof. Dr. Dilek Akyüzlü Ankara Üniversitesi, Türkiye
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) (SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale) | ||
| Dergi Adı | WORLD JOURNAL OF PSYCHIATRY (Q2) | ||
| Dergi ISSN | 2220-3206 Wos Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 15 / 7 / 107597–0 | DOI | 10.5498/wjp.v15.i7.107597 |
| Makale Linki | https://doi.org/10.5498/wjp.v15.i7.107597 | ||
| Özet |
| Individual differences in treatment response in schizophrenia pose a significant challenge in the management of the disease, due to several biological as well as psychosocial factors, including genetic and epigenetic mechanisms. Pharmacoepigenetics investigates how epigenetic mechanisms affect the variability in effectiveness of treatments and adverse side effects. Antipsychotics such as clozapine (atypical) and haloperidol (typical) directly induce epigenetic changes by altering DNA methyltransferases and histone acetyltransferases, while indirectly affecting neuroinflammatory and stress response pathways. Personalized medicine using epigenetic markers (DNA methylation, non-coding RNAs including microRNAs and long non-coding RNAs) holds great promise for improving the drug response and reducing the side effects of antipsychotic treatment. These developments could revolutionize the treatment of … |
| Anahtar Kelimeler |
| Pharmacoepigenetics | Treatment failures | Personalized medicine | Antipsychotic drugs | Schizophrenia |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Google Scholar | 3 |