| Yazarlar (5) |
Sariye Aybüke Yıldırım
Türkiye |
|
Irmak Dal
Türkiye |
Doç. Dr. Selin ÖZKAN KOTİLOĞLU
Türkiye |
|
Bora BAŞKAK
Türkiye |
|
Dilek KAYA-AKYÜZLÜ
Türkiye |
| Özet |
| Individual differences in treatment response in schizophrenia pose a significant challenge in the management of the disease, due to several biological as well as psychosocial factors, including genetic and epigenetic mechanisms. Pharmacoepigenetics investigates how epigenetic mechanisms affect the variability in effectiveness of treatments and adverse side effects. Antipsychotics such as clozapine (atypical) and haloperidol (typical) directly induce epigenetic changes by altering DNA methyltransferases and histone acetyltransferases, while indirectly affecting neuroinflammatory and stress response pathways. Personalized medicine using epigenetic markers (DNA methylation, non-coding RNAs including microRNAs and long non-coding RNAs) holds great promise for improving the drug response and reducing the side effects of antipsychotic treatment. These developments could revolutionize the treatment of schizophrenia by addressing the complexities involved in responding to treatment. However, ethical and technical barriers to implementing strategies based on epigenetic regulation in clinical practice are fundamental challenges that need to be carefully addressed in this field. This review examined the epigenetic mechanisms involved in the efficacy of antipsychotic drugs. |
| Anahtar Kelimeler |
| Pharmacoepigenetics | Treatment failures | Personalized medicine | Antipsychotic drugs | Schizophrenia |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | World Journal of Psychiatry |
| Dergi ISSN | 2220-3206 Wos Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | Türkçe |
| Basım Tarihi | 07-2025 |
| Cilt No | 15 |
| Sayı | 7 |
| Doi Numarası | 10.5498/wjp.v15.i7.107597 |
| Makale Linki | https://doi.org/10.5498/wjp.v15.i7.107597 |
| Atıf Sayıları |
