| Yazarlar (5) |
Samed Şimşek
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
Doç. Dr. Tuncay KARAKURT
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Yusuf BAYAR
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Hüseyin Akşit
Erzincan Binali Yıldırım Üniversitesi, Türkiye |
|
Ekrem Köksal
Türkiye |
| Özet |
| The antifungal activity of axillarin, a polymethoxylated flavone isolated from the methanol extract of Tanacetum alyssifolium, was evaluated in vitro against several plant pathogenic fungi: Fusarium oxysporum f. sp. radicis-lycopersici (FORL), Alternaria alternata (A.A), Fusarium oxysporum f. sp. niveum (FON), Phytophthora infestans, and Cylindrocarpon spp. Antifungal efficacy was assessed at concentrations of 200 and 400 µg/mL using the agar Petri dish method. Axillarin inhibited fungal mycelial growth in a dose-dependent manner, with the highest inhibition observed for A. alternata (33.31%), followed by FORL (29.46%), Cylindrocarpon spp. (26.64%), and FON (18.21%). No inhibitory effect was detected against P. infestans. To support the experimental findings, molecular modeling was performed using GaussView 5.0 and GAUSSIAN 09 to determine the optimized 3D conformation of axillarin through potential energy surface (PES) analysis. This optimized structure was then used in molecular docking simulations to explore interactions with fungal protein receptors. The results suggest that axillarin may serve as a natural antifungal agent with potential applications in the development of environmentally friendly alternatives to synthetic fungicides. This approach supports sustainable plant protection strategies and reduces ecological risks associated with chemical pesticide use. |
| Anahtar Kelimeler |
| antifungal activity | axillarin | molecular docking | plant pathogens | Tanacetum alyssifolium |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Environmental Engineering and Management Journal |
| Dergi ISSN | 1843-3707 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2025 |
| Cilt No | 24 |
| Sayı | 5 |
| Sayfalar | 1035 / 1041 |
| Doi Numarası | 10.30638/eemj.2025.079 |
