| Yazarlar |
Doç. Dr. Bilal İLANBEY
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Latife Meral Kayıkçıoğlu
Ege Üniversitesi, Türkiye |
|
Ebru Sezer
Ege Üniversitesi, Türkiye |
|
Ferhan Girgin Sağın
Ege Üniversitesi, Türkiye |
|
Feriştah Ferda Özkınay
Ege Üniversitesi, Türkiye |
|
Sacide Pehlivan
İstanbul Üniversitesi, Türkiye |
|
Eser Yıldırım Sözmen
Ege Üniversitesi, Türkiye |
| Özet |
| Objectives: There is growing evidence that oxidative modification of low-density lipoprotein (LDL) plays a central rolein the pathogenesis of atherosclerosis, which is increasingly seen at younger ages, and that high-density lipoprotein(HDL) levels are inversely associated with the risk of coronary artery disease (CAD). Cholesteryl ester transfer protein(CETP) has a role in the regulation of plasma HDL levels. The most studied polymorphism in the CETP gene is the Taq1Bpolymorphism, which has consistently been correlated with HDL levels. This case control study of a young (<50 years)Turkish population group with CAD was designed to assess whether there is a relationship between LDL oxidation andCETP Taq1B polymorphism.Methods: A total of 97 patients with CAD and 43 healthy volunteers were included in the study. Traditional risk factorsfor CAD (age, gender, smoking, hypertension) were evaluated in the patient group. Oxidative markers of LDL were determinedin both groups, as well as routine biochemical parameters. Following DNA extraction from white cells, CETPTaq1B polymorphism was determined using polymerase chain reaction amplification and restriction enzyme digestion.Fragments 174 and 361bp were identified as B1, and unrestricted 535 bp fragments as B2.Results: There was no statistical significance between the B1B1, B1B2, B2B2 genotypes in the patient group in terms ofbody mass index, waist-to-hip ratio, or biochemical parameters. Though the HDL cholesterol levels were higher in theB2B2 genotype, there was no statistically significant difference in comparison with the control group.Conclusion: The genetic polymorphism of CETP had no significant effect on CETP function and the CETP polymorphismshould not be proposed as an independent risk factor for cardiovascular events. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | International Journal of Medical Biochemistry |
| Dergi ISSN | 2587-2362 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2020 |
| Sayfalar | 8 / 13 |
| Doi Numarası | 10.14744/ijmb.2019.49469 |
| Makale Linki | http://dx.doi.org/10.14744/ijmb.2019.49469 |
| Atıf Sayıları |
