The role of cholesteryl ester transfer protein TaqIB polymorphism in young atherosclerotic heart disease
Yazarlar (7)
Doç. Dr. Bilal İLANBEY Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Latife Meral Kayıkçıoğlu Ege Üniversitesi, Türkiye
Prof. Dr. Ebru Sezer Ege Üniversitesi, Türkiye
Ferhan Girgin Sağın Ege Üniversitesi, Türkiye
Feriştah Ferda Özkınay
Ege Üniversitesi, Türkiye
Ege Üniversitesi, Türkiye
Prof. Dr. Sacide Pehlivan İstanbul Üniversitesi, Türkiye
Prof. Dr. Eser Yıldırım Sözmen Ege Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
|
||
| Dergi Adı | International Journal of Medical Biochemistry | ||
| Dergi ISSN | 2587-2362 Scopus Dergi | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2019 |
| Cilt / Sayı / Sayfa | 3 / 1 / 8–13 | DOI | 10.14744/ijmb.2019.49469 |
| Makale Linki | http://dx.doi.org/10.14744/ijmb.2019.49469 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
|
||
| Özet |
| Objectives: There is growing evidence that oxidative modification of low-density lipoprotein (LDL) plays a central role in the pathogenesis of atherosclerosis, which is increasingly seen at younger ages, and that high-density lipoprotein (HDL) levels are inversely associated with the risk of coronary artery disease (CAD). Cholesteryl ester transfer protein (CETP) has a role in the regulation of plasma HDL levels. The most studied polymorphism in the CETP gene is the Taq1B polymorphism, which has consistently been correlated with HDL levels. This case control study of a young (< 50 years) Turkish population group with CAD was designed to assess whether there is a relationship between LDL oxidation and CETP Taq1B polymorphism.Methods: A total of 97 patients with CAD and 43 healthy volunteers were included in the study. Traditional risk factors for CAD (age, gender, smoking, hypertension) were evaluated in the patient group. Oxidative markers of LDL were determined in both groups, as well as routine biochemical parameters. Following DNA extraction from white cells, CETP Taq1B polymorphism was determined using polymerase chain reaction amplification and restriction enzyme digestion. Fragments 174 and 361bp were identified as B1, and unrestricted 535 bp fragments as B2. Results: There was no statistical significance between the B1B1, B1B2, B2B2 genotypes in the patient group in terms of body mass index, waist-to-hip ratio, or biochemical parameters. Though the HDL cholesterol levels were higher in the B2B2 genotype, there was no statistically significant difference in comparison with the control group. Conclusion: The … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 4 |