Therapeutic effects of apilarnil, a bee product, on apoptosis and autophagy in cisplatin-induced rat ovarian toxicity
Yazarlar (6)
Dr. Öğr. Üyesi Kübra Tuğçe KALKAN Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Halime TOZAK YILDIZ Kırşehir Ahi Evran Üniversitesi, Türkiye
Dr. Öğr. Üyesi Betül Yalçın Adiyaman Üniversitesi, Türkiye
Arş. Gör. Özge Cengiz Mat Erciyes University, Faculty Of Medicine, Türkiye
Doç. Dr. Gözde Özge Önder Erciyes University, Faculty Of Medicine, Türkiye
Arzu Yay
Erciyes University, Faculty Of Medicine, Türkiye
Erciyes University, Faculty Of Medicine, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Food and Chemical Toxicology (Q2) | ||
| Dergi ISSN | 0278-6915 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2025 |
| Cilt / Sayı / Sayfa | 203 / 1 / 115594–0 | DOI | 10.1016/j.fct.2025.115594 |
| Makale Linki | https://doi.org/10.1016/j.fct.2025.115594 | ||
| UAK Araştırma Alanları |
Anatomi & Morfoloji
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| Özet |
| ObjectiveCisplatin (CP) is a platinum derivative used to treat ovarian, breast, testicular, and bladder cancers. As one of the apitherapy products, apilarnil (API) contains androgenic hormones and is extremely chemically complex. CP alterations in rats' ovarian tissue were evaluated by API, a possible therapeutic medicine.MethodsEach group of female rats consisted of seven rats. One dosage of 7.5 mg/kg/day CP was administered intraperitoneally to the CP group. The API group received 0.5 g/kg/day of apilarnil orally for ten days. Ovarian tissues were then examined histopathologically, immunohistochemically, and biochemically. Beclin-1, p62, and LC-3, along with Caspase-3 and AIF, were immunohistochemically determined. ELISA tests were performed on MDA, GSH-PX, SOD, CAT, AMH, FSH, and LH levels.ResultsThe CP group had significantly fewer primordial follicles than the control group. This group also … |
| Anahtar Kelimeler |
| Apilarnil | Apitherapy | Cisplatin | Ovary | Rat |
Science Direct
Therapeutic effects of apilarnil, a bee product, on apoptosis and autophagy in cisplatin-induced rat ovarian toxicity
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 3 |