Association between Growth Differentiation Factor 15 and Non-Dipping Circadian Pattern in Patients with Newly Diagnosed Essential Hypertension
 
Yazarlar (8)
Prof. Dr. Erdoğan SÖKMEN Kırşehir Ahi Evran Üniversitesi, Türkiye
Cahit Uçar Necmettin Erbakan Üniversitesi, Türkiye
Serkan Sivri Kirsehir Ahi Evran University, Türkiye
Mustafa Çelik Kırşehir Ahi Evran Üniversitesi, Türkiye
Yalçın Boduroğlu Kirsehir Ahi Evran University, Türkiye
Murat Erer
Kırşehir Ahi Evran Üniversitesi, Türkiye
Dr. Öğr. Üyesi Alp YILDIRIM Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Bilal İLANBEY Kırşehir Ahi Evran Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı MEDICAL PRINCIPLES AND PRACTICE (Q3)
Dergi ISSN 1011-7571 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 11-2019
Kabul Tarihi 12-04-2026 Yayınlanma Tarihi
Cilt / Sayı / Sayfa 28 / 6 / 566–572 DOI 10.1159/000501096
Makale Linki https://www.karger.com/Article/Pdf/501096
Özet
Objective: Non-dipper hypertension (HT) confers greater risk compared with dipper HT. Growth differentiation factor 15 (GDF-15) recently emerged as a novel and independent marker of cardiovascular disease, both in diagnostic and prognostic scopes. Our aim was to evaluate the relationship of circadian blood pressure (BP) pattern with serum GDF-15 level in newly diagnosed HT patients without left ventricular hypertrophy. Subjects and Methods: Newly diagnosed non-dipper (n = 66) and dipper (n = 60) HT patients were selected according to 24-h ambulatory BP monitoring (ABPM). The controls comprised healthy normotensive subjects (n = 31). Data was collected through physical examination, laboratory analysis, ABPM, and echocardiography. GDF-15 was measured using ELISA. Results: Greater GDF-15 level was found in the non-dippers compared with the dippers and the controls …
Anahtar Kelimeler
GDF-15 | Non-dipper hypertension | Circadian pattern | Dipping hypertension