| Yazarlar |
Doç. Dr. Hacı Mehmet ÇALIŞKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Serkan Sivri
Türkiye |
Doç. Dr. Erdoğan SÖKMEN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Mustafa Çelik
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Doç. Dr. Bilal İLANBEY
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Sinan Cemgil Özbek
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Burak Çelik
|
| Özet |
| We aimed to examine the role of thiol/disulphide homeostasis (TDH) in heart failure and its stages and the prognosis of heart failure. A total of 140 subjects were included in the study. Total and native thiol levels were higher in the control group compared to the patient groups (p < .001). While the average disulphide/total thiol ratio was similar in groups 1 and 2, it was found to be significantly lower in the control group compared to other groups and significantly higher in group 3 compared to other groups (p < .05). Mean native thiol and total thiol levels were found lower in patients with mortality compared to surviving patients (p < .001). In ROC curve analysis, it was determined that the total thiol level had 81.8% sensitivity and 83.1% specificity, and native thiol level had 81.8% sensitivity and 84.3% specificity. We found that TDH was impaired in favour of disulphide in cases of heart failure. |
| Anahtar Kelimeler |
| Heart failure, left ventricular ejection fraction, mortality, thiol, disulphide homeostasis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Archives of Physiology and Biochemistry |
| Dergi ISSN | 1381-3455 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2021 |
| Cilt No | 127 |
| Sayı | 5 |
| Sayfalar | 462 / 467 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/13813455.2020.1773505 |
