| Yazarlar |
Bilal İLANBEY
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Ömer Faruk Elmas
Türkiye |
|
Eser Yıldırım Sözmen
Ege Üniversitesi, Türkiye |
|
Ümran Günay
Türkiye |
|
Abdullah Demirbaş
Türkiye |
|
Mustafa Atasoy
Türkiye |
|
Ümit Türsen
Türkiye |
|
Torello Lotti
|
| Özet |
| Background/aim: Chitotriosidase (ChT) is an enzyme secreted by activated macrophages and neutrophils in response to proinflammatory signals. There is growing evidence indicating that ChT activity reflects the systemic inflammatory status. This study aimed to investigate whether serum ChT activity increased in patients with psoriasis and related comorbidities. Materials and methods: This cross-sectional study included 53 (28 with associated comorbidities and 25 without comorbidities) patients with psoriasis and 52 healthy volunteers. All participants underwent laboratory investigations for serum ChT levels, complete blood count, erythrocyte sedimentation rate, C-reactive protein, and serum lipid levels. Results: The patients with psoriasis showed significantly higher levels of ChT activity as compared to the healthy controls (23.5 ± 11.4 vs. 17.5 ± 10.4 μmol/mL/hour; p = 0.015). Additionally, the ChT activity was significantly higher in patients with comorbidities than in those without (p = 0.042). Conclusion: Our data support the pathogenetic role of inflammatory processes induced by macrophage activation in patients with psoriasis and related comorbidities. We believe that high ChT activity in patients with psoriasis may serve as an early prediction of the possible related comorbidities.Keywords: Chitotriosidase, comorbidity, macrophage, psoriasis |
| Anahtar Kelimeler |
| Chitotriosidase | comorbidity | macrophage | psoriasis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TURKISH JOURNAL OF MEDICAL SCIENCES |
| Dergi ISSN | 1300-0144 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2021 |
| Cilt No | 51 |
| Sayı | 5 |
| Sayfalar | 2318 / 2323 |
| Doi Numarası | 10.3906/sag-2101-137 |
| Makale Linki | http://dx.doi.org/10.3906/sag-2101-137 |
| Atıf Sayıları | |
| WoS | 1 |
