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Profilin as a Novel Biomarker for Assessing Atherosclerosis in Hemodialysis Patients    
Yazarlar (7)
Aydın Güçlü
Kırşehir Ahi Evran Üniversitesi, Turkey
Kağan Tur
Kırşehir Ahi Evran Üniversitesi, Turkey
Ömer Jaradat
Kırşehir Training and Research Hospital, Turkey
Hacı Sütiçen
Kırşehir Training and Research Hospital, Turkey
Muhammet Alpaslan
Kırşehir Ahi Evran Üniversitesi, Turkey
Doç. Dr. Zeynel Abidin ERBESLER Doç. Dr. Zeynel Abidin ERBESLER
Kırşehir Ahi Evran Üniversitesi, Türkiye
Avşar Zerman
Kırşehir Ahi Evran Üniversitesi, Turkey
Devamını Göster
Özet
Aim Studies have shown a significant correlation between atherosclerosis and profilin-1. However, there is no information in the literature on the concentration of profilin in hemodialysis (HD) patients. This research examined the association between profilin-1 and carotid intima-media thickness (CIMT), as a marker of early atherosclerosis in HD patients. Material and methods 50 chronic HD patients and 38 healthy, control patients were included in this study. CIMT was measured by high-resolution ultrasonography. Results The HD patients were older and had higher concentrations of profilin-1, C reactive protein (CRP), uric acid, parathormone, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) than the control patients. In the HD patients, variables impacting CIMT were examined. CIMT and profilin-1 were significantly correlated (r=0.637, p<0.01), as were CIMT and age (r=0.424, p=0.002). Linear regression analysis revealed that profilin-1 is a significant and independent predictor of carotid intima-media thickness (CIMT). Higher profilin-1 levels were associated with increased CIMT values. Conclusion For the first time, it has been shown that HD patients had greater concentrations of profilin-1 than healthy controls. Also, an independent relationship between profilin-1 and CIMT in HD patients was demonstrated.
Anahtar Kelimeler
atherosclerosis | hemodialysis | intima media thickness | Profilin-1
Makale Türü Özgün Makale
Makale Alt Türü SCOPUS dergilerinde yayımlanan tam makale
Dergi Adı Kardiologiya
Dergi ISSN 0022-9040 Wos Dergi Scopus Dergi
Makale Dili İngilizce
Basım Tarihi 01-2025
Cilt No 65
Sayı 5
Sayfalar 16 / 20
Doi Numarası 10.18087/cardio.2025.5.n2605
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Profilin as a Novel Biomarker for Assessing Atherosclerosis in Hemodialysis Patients

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