| Yazarlar (7) |
Aydın Güçlü
Türkiye |
Dr. Öğr. Üyesi Kağan TUR
Türkiye |
|
Ömer Jaradat
Türkiye |
|
Hacı Sütiçen
Türkiye |
|
Muhammed Alpaslan
Türkiye |
Doç. Dr. Zeynel Abidin ERBESLER
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Avşar ZERMAN
Türkiye |
| Özet |
| Aim Studies have shown a significant correlation between atherosclerosis and profilin-1. However, there is no information in the literature on the concentration of profilin in hemodialysis (HD) patients. This research examined the association between profilin-1 and carotid intima-media thickness (CIMT), as a marker of early atherosclerosis in HD patients. Material and methods 50 chronic HD patients and 38 healthy, control patients were included in this study. CIMT was measured by high-resolution ultrasonography. Results The HD patients were older and had higher concentrations of profilin-1, C reactive protein (CRP), uric acid, parathormone, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) than the control patients. In the HD patients, variables impacting CIMT were examined. CIMT and profilin-1 were significantly correlated (r=0.637, p<0.01), as were CIMT and age (r=0.424, p=0.002). Linear regression analysis revealed that profilin-1 is a significant and independent predictor of carotid intima-media thickness (CIMT). Higher profilin-1 levels were associated with increased CIMT values. Conclusion For the first time, it has been shown that HD patients had greater concentrations of profilin-1 than healthy controls. Also, an independent relationship between profilin-1 and CIMT in HD patients was demonstrated. |
| Anahtar Kelimeler |
| atherosclerosis | hemodialysis | intima media thickness | Profilin-1 |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Diğer hakemli uluslarası dergilerde yayımlanan tam makale |
| Dergi Adı | Kardiologiia |
| Dergi ISSN | 0022-9040 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | Russian Scientific Citation Index (RSCI) |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2025 |
| Cilt No | 65 |
| Sayı | 5 |
| Sayfalar | 16 / 20 |
| Doi Numarası | 10.18087/cardio.2025.5.n2605 |
| Makale Linki | https://doi.org/10.18087/cardio.2025.5.n2605 |
| Atıf Sayıları |
