| Yazarlar (4) |
Dr. Öğr. Üyesi Ayşe Nur COŞKUN DEMİRKALP
Kırşehir Ahi Evran Üniversitesi, Türkiye |
Akın Tekcan
Amasya University, Türkiye |
|
Mustafa Çakır
Erciyes University, Türkiye |
|
Hamiyet Altuntaş
Erciyes Üniversitesi, Türkiye |
| Özet |
| Paracetamol (acetaminophen) is a widely used analgesic and antipyretic drug. Although many studies are available showing that paracetamol causes hepatic damage, few studies exist on renal damage. Protein tyrosine phosphatase receptor type O (PTPRO) protein has tyrosine phosphatase activity and plays a role in the regulation of the renal glomerular pressure/filtration rate relationship in podocyte structure. The PTPRO gene also exhibits characteristics of a candidate tumor suppressor gene. In this study, apoptosis, cell cycle, colony formation, and PTPRO gene expression of the human embryonic kidney (HEK 293) cells were assessed by treating with paracetamol at different concentrations for 24 and 26 h in at least three independent trials. Paracetamol induced dose‐dependent apoptosis at all concentrations (5, 10, 15, 20, and 30 mM) for both 24 and 26 h (p < 0.05–p < 0.001). Paracetamol … |
| Anahtar Kelimeler |
| acetaminophen (paracetamol) | apoptosis | cell cycle | colony formation | HEK 293 cells | PTPRO | renal cancer |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Biochemical and Molecular Toxicology |
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 08-2025 |
| Cilt No | 39 |
| Sayı | 8 |
| Sayfalar | 1 / 10 |
| DOI Numarası | 10.1002/jbt.70366 |
| Makale Linki | https://doi.org/10.1002/jbt.70366 |
| Atıf Sayıları | |
| Google Scholar | 1 |
