| Yazarlar (2) |
Nevin Cankaya
|
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Death-associated protein kinase 1 (DAPK1) is a calcium/calmodulin (Ca2+/CaM)-dependent serine/threonine kinase that acts as a tumor suppressor and controls tumor growth in the early stages. However, its role in promoting tumor epithelial-mesenchymal transition (EMT) and stem cell expression becomes particularly significant in advanced-stage cancers, such as colon and thyroid cancer. The inhibition of DAPK1 might be beneficial to treat cancer. Our research focused on creating a first-in-class, small-molecule DAPK1 inhibitor for cancer therapy. In the present study, we have used a synthesized molecule, N-cyclohexylacrylamide (NCA), to identify DAPK1 and associated protein groups. We obtained the 3D protein structures from the protein data bank. Furthermore, ADMET and drug-likeness properties of the compound were analyzed by using the rules of Lipinski, Veber, and Ghose (http://www.swissadme.ch … |
| Anahtar Kelimeler |
| N-Cyclohexylacrylamide | Molecular docking | Drug-likeness | ADMET | DAPK1 |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | DISCOVER APPLIED SCIENCES |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2025 |
| Cilt No | 7 |
| Sayı | 6 |
| Doi Numarası | 10.1007/s42452-025-07143-6 |
| Makale Linki | https://link.springer.com/content/pdf/10.1007/s42452-025-07143-6.pdf |
| Atıf Sayıları | |
| Google Scholar | 1 |
