| Yazarlar (6) |
Ender Anılır
|
|
Filiz Özen
|
|
Ibrahim Ali Ozemir
|
Doç. Dr. İbrahim Halil YILDIRIM
Dicle Üniversitesi, Türkiye |
|
Cagri Bilgic
|
|
Orhan Alimoglu
|
| Özet |
| Objectives: There has been coverage of Toll-like receptor 4 and Toll-like receptor 2 gene polymorphisms in inflammatory episodes in a number of studies. In view of the inflammatory nature of acute pancreatitis, we aimed todetermine the predictive value of mutations in Asp299Gly and Thr399Ile of the Toll-like receptor 4 gene, and theintron 2 microsatellite polymorphism of the Toll-like receptor 2 gene on the occurrence of acute biliary pancreatitis.Material and Methods: The study included 86 patients for the Toll-like receptor 4 Thr399Ile polymorphism, 100patients for the Toll-like receptor 4 Asp299Gly polymorphism with acute biliary pancreatitis, and 101 healthy volunteers. At the same time, 93 patients and 92 healthy volunteers were included in the study to research the Toll-likereceptor 2 intron 2 microsatellite polymorphism. Genotypes were determined using the restriction fragment lengthpolymorphism analysis of PCR products and by an allele-specific PCR.Results: The Toll-like receptor 4 Thr399Ile homozygotes mutant variants (p=0.005) and Toll-like receptor 2 MMgenotype (p<0.001) were detected with a significantly higher frequency in patients with acute biliary pancreatitisthan in the healthy blood donors.Conclusion: The Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and the Toll-like receptor 2 intron 2microsatellite polymorphism are statistically associated with ABP. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | Turkish Journal of Surgery |
| Dergi ISSN | 2564-6850 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 09-2018 |
| Cilt No | 34 |
| Sayı | 3 |
| Sayfalar | 191 / 197 |
| Doi Numarası | 10.5152/turkjsurg.2017.3828 |
| Makale Linki | https://www.turkjsurg.com/abstract/1580/eng |
| Atıf Sayıları |
