TLR4 Asp299Gly and Thr399Ile and TLR2 intron 2 microsatellite gene polymorphism in patients with acute biliary pancreatitis: Does it cause the disease?
Yazarlar (6)
T.C. Sağlık Bakanlığı, Türkiye
İstanbul Medeniyet Üniversitesi, Türkiye
İstanbul Medeniyet Üniversitesi, Türkiye
Doç. Dr. İbrahim Halil YILDIRIM
Dicle Üniversitesi, Türkiye
Koç Üniversitesi, Türkiye
İstanbul Medeniyet Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Turkish Journal of Surgery | ||
| Dergi ISSN | 2564-6850 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2018 |
| Cilt / Sayı / Sayfa | 34 / 3 / 191–197 | DOI | 10.5152/turkjsurg.2017.3828 |
| Makale Linki | https://www.turkjsurg.com/abstract/1580/eng | ||
| Özet |
| Objectives: There has been coverage of Toll-like receptor 4 and Toll-like receptor 2 gene polymorphisms in inflammatory episodes in a number of studies. In view of the inflammatory nature of acute pancreatitis, we aimed todetermine the predictive value of mutations in Asp299Gly and Thr399Ile of the Toll-like receptor 4 gene, and theintron 2 microsatellite polymorphism of the Toll-like receptor 2 gene on the occurrence of acute biliary pancreatitis.Material and Methods: The study included 86 patients for the Toll-like receptor 4 Thr399Ile polymorphism, 100patients for the Toll-like receptor 4 Asp299Gly polymorphism with acute biliary pancreatitis, and 101 healthy volunteers. At the same time, 93 patients and 92 healthy volunteers were included in the study to research the Toll-likereceptor 2 intron 2 microsatellite polymorphism. Genotypes were determined using the restriction fragment lengthpolymorphism analysis of PCR products and by an allele-specific PCR.Results: The Toll-like receptor 4 Thr399Ile homozygotes mutant variants (p=0.005) and Toll-like receptor 2 MMgenotype (p<0.001) were detected with a significantly higher frequency in patients with acute biliary pancreatitisthan in the healthy blood donors.Conclusion: The Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and the Toll-like receptor 2 intron 2microsatellite polymorphism are statistically associated with ABP. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |