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Akademisyenler > Harun ÇİFTÇİ > Yayın Detayı

Synthesis of thiophene-based imine and phosphoazometine compounds: in vitro antiproliferative, antimicrobial, antioxidant, carbonic anhydrase I and II enzyme inhibition evaluations and molecular docking study    
Yazarlar (4)
Dr. Öğr. Üyesi Kübra ÖZTÜRK Dr. Öğr. Üyesi Kübra ÖZTÜRK
Kırşehir Ahi Evran Üniversitesi, Türkiye
Muhammet Saban Tanyildizi
Firat Üniversitesi, Türkiye
Prof. Dr. Harun ÇİFTÇİ Prof. Dr. Harun ÇİFTÇİ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Özlem GÜNDOĞDU AYTAÇ Doç. Dr. Özlem GÜNDOĞDU AYTAÇ
Kırşehir Ahi Evran Üniversitesi, Türkiye
Devamını Göster
Özet
New thiophene-based imine ((E)-N,N-dimethyl-4-((thiophen-2-yl-methylene)amino)aniline) (Y6), amine (N1,N1-dimethyl-N4-(thiophen-2)-ylmethyl)benzene-1,4-diamine) (Y6a), and phosphoacomethine (diphenyl (((4-(dimethylamino)phenyl)amino)(thiophen-2-yl)methyl)phosphate) (Y6b) compounds were synthesized, and their structures were thoroughly analyzed. The synthesized compounds were determined to have antioxidant effects and strong inhibitory effects against human carbonic anhydrases I and II (hCA I and hCA II) isoforms. All compounds exhibited significant antioxidant properties, with compound Y6a showing an IC50 value of 5.13 µg/mL, which was significantly lower than the IC50 of ascorbic acid (17.55 µg/mL). The compounds also demonstrated potent inhibitory effects against hCA I and hCA II isoenzymes, with IC50 values of 1.96 µM (Y6), 8.25 µM (Y6a), and 0.46 µM (Y6b) for hCA I, and 1.89 µM (Y6), 0.56 µM (Y6a), and 1.02 µM (Y6b) for hCA II. In addition to the experimental findings, molecular docking studies of the synthesized compounds were performed. Antimicrobial tests of the synthesized compounds were performed, and it was determined that they have antibacterial activity against bacterial strains. Additionally, all three compounds exhibited promising antiproliferative activity in the MCF-7 breast cancer cell line, with IC50 values of 56.58 µM (Y6), 51.30 µM (Y6a), and 40.01 µM (Y6b). Notably, the IC50 value of Y6b (40.01 µM) was found to be comparable to that of cisplatin, one of the effective chemotherapy drugs, and has the potential to be a drug or drug precursor.
Anahtar Kelimeler
Phosphanate compound | Antioxidant | Antimicrobial | MCF-7 cells | Carbonic anhydrase
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı CHEMICAL PAPERS
Dergi ISSN 0366-6352 Wos Dergi Scopus Dergi
Dergi Grubu Q3
Makale Dili İngilizce
Basım Tarihi 05-2025
Cilt No 79
Sayı 7
Sayfalar 4735 / 4751
Doi Numarası 10.1007/s11696-025-04096-3
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Synthesis of thiophene-based imine and phosphoazometine compounds: in vitro antiproliferative, antimicrobial, antioxidant, carbonic anhydrase I and II enzyme inhibition evaluations and molecular docking study

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