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Selenium modulates oxidative stress induced TRPM2 cation channel currents in transfectedChinese hamster ovary cells     
Yazarlar
Mustafa Nazıroğlu
Süleyman Demirel Üniversitesi, Türkiye
Cemil Özgül
Mustafa Küçükayaz
Doç. Dr. Bilal ÇİĞ Doç. Dr. Bilal ÇİĞ
Süleyman Demirel Üniversitesi, Türkiye
Simon Hebeısen
Ramazan Bal
Özet
It has been recently reported that the essential antioxidant element selenium has protective effects on cytosolic Ca2+ levels in cell lines. However, the effects of selenium on like transient receptor potential melastatin 2 (TRPM2) in response to oxidative stress (H2O2) are not well understood. We investigated the effects of selenium on H2O2-induced TRPM2 channel currents in the Chinese hamster ovary (CHO) cell line using patch-clamp and fura-2 fluorescence imaging techniques.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
Dergi ISSN 1742-7835
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 02-2013
Cilt No 112
Sayı 2
Sayfalar 96 / 102
Doi Numarası 10.1111/j.1742-7843.2012.00934.x