| Yazarlar |
Mustafa Nazıroğlu
Süleyman Demirel Üniversitesi, Türkiye |
Doç. Dr. Bilal ÇİĞ
Süleyman Demirel Üniversitesi, Türkiye |
|
Salih Doğan
|
|
Abdülhadi Cihangir Uğuz
Süleyman Demirel Üniversitesi, Türkiye |
|
Selin Dilek
|
|
D Faouzi
|
| Özet |
| Purpose: Electromagnetic radiation from wireless devices may affect biological systems by increasing free radicals. The present study was designed to determine the effects of 2.45 GHz radiation on the antioxidant redox system, calcium ion signaling, cell count and viability in human leukemia 60 cells. Materials and methods: Twelve cell cultures were equally divided into two main groups as controls (n=6) and irradiated (n=6) and then subdivided into four different subgroups depending on the duration of exposure, namely 1, 2, 12 and 24 hours. The samples were analyzed immediately after the experimental period. Results: The extent of lipid peroxidation, cytosolic free Ca2+ and cell numbers were higher in 2.45 GHz groups than in the controls. The increase of cytosolic free Ca2+ concentrations was radiation time-dependent and was highest at 24-h exposure. The reduced glutathione, glutathione peroxidase, vitamin C and cell viability values did not show any changes in any of the experimental groups. 2-aminoethyl diphenylborinate inhibits Ca 2+ ions influx by blockage of the transient receptor potential melastatin 2. Conclusions: 2.45 GHz electromagnetic radiation appears to induce proliferative effects through oxidative stress and Ca2+ influx although blocking of transient receptor potential melastatin 2 channels by 2-aminoethyl diphenylborinate seems to counteract the effects on Ca2+ ions influx. © 2012 Informa UK, Ltd. |
| Anahtar Kelimeler |
| Blood cancer | Ca influx 2+ | Oxidative stress | TRPM2 channels | Wireless devices |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Int J Radiat Biol. |
| Dergi ISSN | 0955-3002 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2012 |
| Cilt No | 88 |
| Sayı | 6 |
| Sayfalar | 449 / 456 |
| Doi Numarası | 10.3109/09553002.2012.682192 |
