Role of TRPM2 cation channels in dorsal root ganglion of rats after experimental spinal cord injury
Yazarlar (6)
Mustafa Nazıroğlu
Süleyman Demirel Üniversitesi, Türkiye
Abdülhadi Cihangir Uğuz
Suleyman Demirel University, Türkiye
Özgür İsmailoğlu
Suleyman Demirel University, Türkiye
Doç. Dr. Bilal ÇİĞ
Suleyman Demirel University, Türkiye
Cemil Özgül
Suleyman Demirel University, Türkiye
Muhammed Borcak
Suleyman Demirel University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Muscle Nerve | ||
| Dergi ISSN | 1097-4598 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2013 |
| Cilt / Sayı / Sayfa | 48 / 6 / 945–950 | DOI | 10.1002/mus.23844 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mus.23844 | ||
| Özet |
| Introduction: We sought to determine the contribution of oxidative stress-dependent activation of TRPM2 and L-type voltage-gated Ca2+ channels (VGCC) in dorsal root ganglion (DRG) neurons of rats after spinal cord injury (SCI). Methods: The rats were divided into 4 groups: control; sham control; SCI; and SCI+nimodipine groups. The neurons of the SCI groups were also incubated with non-specific TRPM2 channel blockers, 2-aminoethoxydiphenylborate (2-APB) and N-(p-amylcinnamoyl)anthranilic acid (ACA), before H2O2 stimulation. Results:The [Ca2+](i) concentrations were higher in the SCI group than in the control groups, although their concentrations were decreased by nimodipine and 2-APB. The H2O2-induced TRPM2 current densities in patch-clamp experiments were decreased by ACA and 2-APB incubation. In the nimodipine group, the TRPM2 channels of neurons were not activated by H2O2 or cumene hydroperoxide. Conclusions: Increased Ca2+ influx and currents in DRG neurons after spinal injury indicated TRPM2 and voltage-gated Ca2+ channel activation. Muscle Nerve48: 945-950, 2013 |
| Anahtar Kelimeler |
| Ca2+ signaling | nimodipine | oxidative stress | peripheral pain | spinal injury | TRPM2 cation channels |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 20 |
| SCOPUS | 20 |