| Yazarlar (5) |
Selvinaz Yakan
Agri Ibrahim Cecen University, Türkiye |
Prof. Dr. Yusuf Kenan DAĞLIOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Kivilcim Eren Erdogan
Cukurova University, Türkiye |
|
Ruya Saglamtas
Agri Ibrahim Cecen University, Türkiye |
|
Ilhami Gulcin
Ataturk University, Türkiye |
| Özet |
| This study explored the effects of comfrey (Symphytum officinale) on treating third-degree burns in a rat model, demonstrating promising results. A hot iron created standardized burns, after which three groups of rats received different treatments: no treatment (control), vaseline, or a 20% comfrey ointment. Histopathological assessments at the 7 days and 14 days marks showed accelerated healing in the comfrey-treated group compared to the control, indicating comfrey's potential for enhancing wound recovery. Additionally, comfrey's antioxidant capacity was evaluated using assays such as Fe3+ and Cu2+ reducing power and free radical scavenging activities (DPPH center dot and ABTS center dot(+) assays). The IC50 values for DPPH center dot scavenging were 69.30 pg.mL(-1) (water extract) and 46.20 mu g.mL(-1), while for ABTS center dot(+) scavenging they were 77.00 pg.mL(-1) and 69.30 pg.mL(-1) (ethanol extract). These results confirm that comfrey exhibits significant antioxidant activity, likely contributing to its wound-healing properties. Overall, this study suggests comfrey as a safe traditional treatment option for burn healing, with its benefits likely stemmingfrom its antioxidant activity. The results indicate this combination is a safe traditional medicine for clinical applications at proper doses. |
| Anahtar Kelimeler |
| Comfrey (Symphytum officinale) | antioxidant activity | wound healing |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS |
| Dergi ISSN | 0798-2259 Wos Dergi Scopus Dergi |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2025 |
| Cilt No | 35 |
| Sayı | 1 |
| DOI Numarası | 10.52973/rcfcv-e35566 |
| Atıf Sayıları |
