In Vivo and in Silico Evaluation of the Effect of p-Acetamide and MPAEMA on the Model Organism Galleria Mellonella (Lepidoptera: Pyralidae)
Yazarlar (3)
Usak University, Türkiye
Prof. Dr. Serap YALÇIN AZARKAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Fahriye ERCAN
Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | KSU TARIM VE DOGA DERGISI-KSU JOURNAL OF AGRICULTURE AND NATURE | ||
| Dergi ISSN | 2619-9149 Wos Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 28 / 3 / 625–635 | DOI | 10.18016/ksutarimdoga.vi.1591091 |
| Makale Linki | http://dogadergi.ksu.edu.tr/en/download/article-file/4392723 | ||
| Özet |
| In this study, 2-chloro-N-(4-methoxyphenyl)acetamide (p-acetamide) and 2-(4-methoxyphenylamino)-2-oxoethyl methacrylate (MPAEMA) were resynthesized to evaluate their effect on the agricultural pest Galleria mellonella. The toxicities of p-acetamide and MPAEMA against the larval stage of G. mellonella were evaluated concurrently. The results indicate that p-acetamide has a lethal effect on insect larvae at lower doses. LC50 doses of p-acetamide and MPAEMA were 873,572 and 687,355 uM, respectively. These values represent the concentrations of the substances at which 50% of the larvae exposed to them are expected to die. The molecular docking interactions of p-acetamide and MPAEMA with the proteins superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione-S-transferase (GST) were analyzed. The binding energy between MPAEMA and glutathione peroxidase was determined to be-6.8 kcal/mol. This suggests that MPAEMA may have an inhibitory effect on glutathione peroxidase and could be further investigated for developing pesticides that target this enzyme. |
| Anahtar Kelimeler |
| Galleria mellonella | Toxicity | Molecular docking | p-acetamide | MPAEMA |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 2 |