| Yazarlar |
Doç. Dr. Bilal ÇİĞ
Süleyman Demirel Üniversitesi, Türkiye |
Mustafa Nazıroğlu
Süleyman Demirel Üniversitesi, Türkiye |
| Özet |
| TRPV1 is a Ca2+ permeable channel and gated by noxious heat, oxidative stress and capsaicin (CAP). Some reports have indicated that non-ionized electromagnetic radiation (EMR)-induces heat and oxidative stress effects. We aimed to investigate the effects of distance from sources on calcium signaling, cytosolic ROS production, cell viability, apoptosis, plus caspase-3 and -9 values induced by mobile phones and Wi-Fi in breast cancer cells MCF-7 human breast cancer cell lines were divided into A, B, C and D groups as control, 900, 1800 and 2450 MHz groups, respectively. Cells in Group A were used as control and were kept in cell culture conditions without EMR exposure. Groups B, C and D were exposed to the EMR frequencies at different distances (0 cm, 1 cm, 5 cm, 10 cm, 20 cm and 25 cm) for 1 h before CAP stimulation. The cytosolic ROS production, Ca2+ concentrations, apoptosis, caspase-3 and caspase-9 values were higher in groups B, C and D than in A group at 0 cm, 1 cm and 5 cm distances although cell viability (MTT) values were increased by the distances. There was no statistically significant difference in the values between control, 20 and 25 cm. Wi-Fi and mobile phone EMR placed within 10 cm of the cells induced excessive oxidative responses and apoptosis via TRPV1-induced cytosolic Ca2+ accumulation in the cancer cells. Using cell phones and Wi-Fi sources which are farther away than 10 cm may provide useful protection against oxidative stress, apoptosis and overload of intracellular Ca2+. This article is part of a Special Issue entitled: Membrane channels and transporters in cancers. (C) 2015 Elsevier B.V. All rights reserved. |
| Anahtar Kelimeler |
| Mobile phone | Wireless internet (Wi-Fi) | Calcium signaling | Oxidative stress | Apoptosis | Breast cancer |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES |
| Dergi ISSN | 0005-2736 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2015 |
| Cilt No | 1848 |
| Sayı | 10 |
| Sayfalar | 2756 / 2765 |
| Doi Numarası | 10.1016/j.bbamem.2015.02.013 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S000527361500053X |
| Atıf Sayıları | |
| WoS | 61 |
| SCOPUS | 64 |
