| Yazarlar |
Mustafa Nazıroğlu
Süleyman Demirel Üniversitesi, Türkiye |
|
Ömer Çelik
Süleyman Demirel Üniversitesi, Türkiye |
|
Cemil Özgül
|
Doç. Dr. Bilal ÇİĞ
Süleyman Demirel Üniversitesi, Türkiye |
|
Salih Doğan
|
|
Ramazan Bal
|
|
Nurhan Gümral
|
|
A B Rodrıguez
|
|
J A Pariente
|
| Özet |
| We aimed to investigate the protective effects of melatonin and 2.45 GHz electromagnetic radiation (EMR) on brain and dorsal root ganglion (DRG) neuron antioxidant redox system. Ca2+ influx, cell viability and electroencephalography (EEG) records in the rat. Thirty two rats were equally divided into four different groups namely group A1: Cage control, group A2: Sham control, group B: 2.45 GHz EMR, group C: 2.45 GHz EMR+ melatonin. Groups B and C were exposed to 2.45 GHz EMR during 60 min/day for 30 days. End of the experiments, EEG records and the brain cortex and DRG samples were taken. Lipid peroxidation (LP), cell viability and cytosolic Ca2+ values in DRG neurons were higher in group B than in groups A1 and A2 although their concentrations were increased by melatonin, 2-aminoethyldiphenyl borinate (2-APB), diltiazem and verapamil supplementation. Spike numbers of EEG records in group C were lower than in group B. Brain cortex vitamin E concentration was higher in group C than in group B. In conclusion, Melatonin supplementation in DRG neurons and brain seems to have protective effects on the 2.45 GHz-induced increase Ca2+ influx, EEG records and cell viability of the hormone through TRPM2 and voltage gated Ca2+ channels. (C) 2011 Elsevier Inc. All rights reserved. |
| Anahtar Kelimeler |
| Ca influx 2+ | Dorsal root ganglion neuron | Electroencephalography records | Melatonin | Oxidative stress | TRPM2 channels | Wireless devices |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | PHYSIOLOGY & BEHAVIOR |
| Dergi ISSN | 0031-9384 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2012 |
| Cilt No | 105 |
| Sayı | 3 |
| Sayfalar | 683 / 692 |
| Doi Numarası | 10.1016/j.physbeh.2011.10.005 |
| Atıf Sayıları | |
| WoS | 72 |
| SCOPUS | 75 |
