| Yazarlar (6) |
Merve Ak
|
|
Gizem Ozer-Uzaldi
|
|
Mukaddes Asena Yildirim
|
Doç. Dr. Selin ÖZKAN KOTİLOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Mustafa Danisman
|
|
Dilek Kaya-Akyuzlu
|
| Özet |
| To investigate the impact of PDYN 68-bpVNTR, BDNF rs6265, OPRD1 rs569356 and OPRM1 rs2075572 variations on the susceptibility to opioid-methamphetamine co-use, a total of 532 individuals, including opioid (n=104), and methamphetamine (n=166) users as well as opioid and methamphetamine co- users (n=158) and healthy individuals (n=104), were included. BDNF rs6265, OPRD1 rs569356 and OPRM1 rs2075572 were genotyped by PCR-RFLP method, while PDYN 68-bp VNTR was genotyped by PCR. The assessment of impulsiveness, craving, withdrawal, anxiety and depressive symptoms was conducted using scales. A significant difference was identified between the substance-using groups and the control group in view of the alleles of PDYN 68-bp VNTR (p=0.001). The allele frequencies of the PDYN 68-bp VNTR exhibited a difference between opioid and methamphetamine users (p=0.018 ... |
| Anahtar Kelimeler |
| PDYN | Opioid-methamphetamine co-use | Individual difference | Genetic variations |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Environmental Toxicology and Pharmacology |
| Dergi ISSN | 1382-6689 |
| Dergi Tarandığı Indeksler | |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2025 |
| Cilt No | 116 |
| Sayfalar | 104714 / 0 |
| Doi Numarası | 10.1016/j.etap.2025.104714 |
| Atıf Sayıları |
