Synthesis of a Novel Inda-Box Ligand and Application in the Copper Catalyzed Asymmetric Henry Reaction
Yazarlar (2)
Prof. Dr. Betül KARATAŞ
Kırşehir Ahi Evran Üniversitesi, Türkiye
| Bildiri Türü | Tebliğ/Bildiri | Bildiri Dili | İngilizce |
| Bildiri Alt Türü | Özet Metin Olarak Yayınlanan Tebliğ (Uluslararası Kongre/Sempozyum) | ||
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum | ||
| Kongre Adı | WITAM-2016 2nd INTERNATIONAL CONGRESS ON THE WORLD OF TECHNOLOGY AND ADVANCED MATERIALS | ||
| Kongre Tarihi | 28-09-2016 / 02-10-2016 | ||
| Basıldığı Ülke | Türkiye | Basıldığı Şehir | Kırşehir |
| Özet |
| In this study, a novel chiral inda (box) ligand 1 with a norbornadiene backbone was synthesized and used as a chiral ligand in the copper-catalyzed enantioselective Henry reaction, one of the important C-C bond forming reactions in organic chemistry [1-2]. The synthesis of the ligand was achieved in 2 steps starting from diacyl chloride 2 and (1R, 2S)-cis-1-amino-2-indanol (3). The formed bis (hydroxyamide) was cyclized in the presence of Ti (iPrO) 4 at 135 C to give inda (box) ligand 1 in 75% yield (Scheme 1). |
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