| Yazarlar (7) |
Mehmet Serhat Topaloğlu
Türkiye |
|
Gül Devrimsel
Türkiye |
|
Ayşegül Küçükali Türkyılmaz
Türkiye |
Prof. Dr. Aynur KIRBAŞ
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Hacer Bilgin Topaloğlu
|
|
Münevver Serdaroğlu Beyazal
Recep Tayyip Erdoğan Üniversitesi, Türkiye |
|
Murat Yıldırım
Türkiye |
| Özet |
| Aim: Our aim in this study was to demonstrate that rheumatoid arthritis (RA) patients have an increase in serum tryptase concentrations and that this correlates with the level of disease activity. Material and Method: The research involved 43 patients RA and 37 healthy participants as the control group. The average ages of the patients and the control group were 52.53±11.10 and 48.41±12.79 years, respectively. Sociodemographic information of all participants was recorded. Disease Activity Score 28 (DAS28), Health Assessment Questionnaire (HAQ) and Visual Analog Scale (VAS) scores were calculated after detailed examination to determine disease activity. Total serum tryptase concentrations were evaluated using enzyme-linked immunosorbent assay (ELISA). Results: Serum tryptase levels were higher in the RA group compared to the healthy group and a statistically significant difference was found (p<0.001). A meaningful connection was detected between serum tryptase concentrations and DAS28, VAS and HAQ scores in RA patients (p<0.05). Erythrocyte sedimentation rate (ESR) and serum tryptase levels showed a notable and significant association (p<0.05). There was no statistically significant correlation between serum tryptase concentrations and C-reactive protein (CRP) (p>0.05). Conclusion: The findings reveal that serum tryptase levels are upregulated in subjects with RA and demonstrate a correlation with disease activity. Serum tryptase may contribute to inflammation in RA. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | MEDICAL RECORDS-International Medical Journal |
| Dergi ISSN | 2687-4555 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2025 |
| Cilt No | 7 |
| Sayı | 2 |
| Sayfalar | 370 / 376 |
| Doi Numarası | 10.37990/medr.1629318 |
| Makale Linki | https://dergipark.org.tr/en/pub/medr/issue/90644/1629318 |
| Atıf Sayıları |
