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Is there a risk of developmental problems in infants born to mothers with gestational diabetes mellitus and/or pre-eclampsia?    
Yazarlar (8)
Bilge Nur Yardımcı Lokmanoğlu
Hacettepe Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yusuf TOPAL Dr. Öğr. Üyesi Yusuf TOPAL
Kırşehir Ahi Evran Üniversitesi, Türkiye
Esra Kınacı Biber
Düzce Üniversitesi, Türkiye
Zeynep Arıkan
Karamanoğlu Mehmetbey Üniversitesi, Türkiye
Gülsen Sırtbaş Işık
Van Yüzüncü Yıl Üniversitesi, Türkiye
Doğan Porsnok
Bingöl Üniversitesi, Türkiye
Hasan Tolga Çelik
Hacettepe Üniversitesi, Türkiye
Akmer Mutlu
Hacettepe Üniversitesi, Türkiye
Devamını Göster
Özet
The aims of this study were (i) to describe the early spontaneous movements in 3-to 5-month-old infants in groups of infants born to mothers with GDM and/or PE, (ii) to compare them, and (iii) to analyze the differences between infants with these risk factors and typically developing infants born to mothers without GDM and/or PE and other risk factors. This cohort study included 255 infants in 4 groups: (i) 96 infants born to mothers with GDM, (ii) 78 infants born to mothers with PE, (iii) 31 infants born to mothers with GDM and PE, and (iv) 50 typically developing infants. Early spontaneous movements, including not only fidgety movements but also concurrent movement and postural patterns, were assessed using the General Movements Assessment (GMA), which determines the Motor Optimality Score-Revised (MOS-R). Comparisons were made using one-way ANOVA for normally distributed continuous variables, Kruskal-Wallis test for non-normally distributed data, and Pearson chi-squared for categorical variables. Univariate logistic regression analyses were used to determine the odds ratios (OR) with 95% confidence intervals (CI). There were no differences between the three groups, which included infants whose mothers had at least one of these risk factors (p>0.05). Infants born to mothers with GDM, infants born to mothers with PE, and infants born to mothers with both GDM and PE had more aberrant fidgety movements, reduced age-adequate movement repertoire, and more abnormal postural patterns than typically developing infants (p<0.05), in addition to lower MOS-R. When looking at those with ≤24 in MOS-R, the odds ratios were ≥2.74. Findings suggest that early spontaneous movements, GMA, may play a crucial role in understanding developmental outcomes of these infants and in determining infants who need early intervention.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı PLOS ONE
Dergi ISSN 1932-6203 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili İngilizce
Basım Tarihi 01-2025
Cilt No 20
Sayı 1
Doi Numarası 10.1371/journal.pone.0318003
Makale Linki https://doi.org/10.1371/journal.pone.0318003