| Yazarlar (4) |
Seval Kucukparmaksiz
|
|
Dilek Kaya Akyuzlu
|
Doç. Dr. Selin ÖZKAN KOTİLOĞLU
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Mustafa Danisman
|
| Özet |
| AimThe aim of this study is to find out the effect of SOD1 rs36232792 and SOD2 rs5746136 on the risk of opioid use disorder (OUD).MethodsIndividuals with OUD (n = 101) and controls (n = 104) were included. SOD1 rs36232792 was genotyped by PCR. A novel PCR-RFLP method for SOD2 rs5746136 was optimized.ResultsA significant difference was observed between individuals with OUD and controls in view of the frequency of 'Ins/Del+Del/Del' genotypes of the SOD1 rs36232792 (p = 0.049), but not for SOD2 rs5746136 (p = 0.254). The intensity of anxiety and depressive symptoms was significantly higher in individuals with OUD compared to controls (p = 0.001).ConclusionThe SOD1 rs36232792 polymorphism could contribute to the risk of OUD in a Turkish population. A novel PCR-RFLP method for SOD2 rs5746136 confirmed by sequencing can be used in a research laboratory without ... |
| Anahtar Kelimeler |
| Opioid use disorder | |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Pharmacogenomics |
| Dergi ISSN | 1462-2416 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2025 |
| Cilt No | 26 |
| Sayı | 3 |
| Sayfalar | 1 / 11 |
| Doi Numarası | 10.1080/14622416.2025.2490467 |
| Atıf Sayıları |
