In Silico and In Vitro Antifungal Investigations of Verbascoside Isolated From Verbascum Ozturkii
Yazarlar (4)
Samed Şimşek Erzincan Binali Yıldırım Üniversitesi, Türkiye
Hüseyin Akşit Erzincan Binali Yıldırım Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yusuf BAYAR Kırşehir Ahi Evran Üniversitesi, Türkiye
Prof. Dr. Tuncay KARAKURT Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2025 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 10 / 17 / – | DOI | 10.1002/slct.202400701 |
| Makale Linki | https://doi.org/10.1002/slct.202400701 | ||
| Özet |
| This study investigates the antifungal properties of verbascoside isolated from Verbascum ozturkii. The primary objective is to evaluate its efficacy against two agriculturally significant plant pathogens, Phytophthora infestans and Verticillium dahliae. Verbascoside was isolated using preparative high‐performance liquid chromatography (HPLC) and its structure was elucidated via nuclear magnetic resonance (NMR) spectroscopy. In vitro antifungal assays demonstrated moderate inhibitory effects with verbascoside (2 mg/mL) reducing mycelial growth by 23.49% for P. infestans and 19.42% for V. dahliae. To elucidate the antifungal mechanism, quantum chemical calculations and molecular docking studies were conducted. Analyses of frontier molecular orbitals (HOMO‐LUMO) and molecular electrostatic potential (MEP) identified critical interaction sites. Molecular docking demonstrated that verbascoside binds … |
| Anahtar Kelimeler |
| Antifungal activity | Molecular docking simulations | Verbascoside | Verbascum ozturkii |
| Atıf Sayıları | |
| Google Scholar | 4 |
| Scopus | 1 |
| Web of Science | 2 |