Gleason score at the margin can predict biochemical recurrence after radical prostatectomy, in addition to preoperative PSA and surgical margin status
Yazarlar (11)
Sidika Seyma Ozkanli
Istanbul Medeniyet University, Türkiye
Itir Ebru Zemheri
Istanbul Medeniyet University, Türkiye
Asif Yildirim
Istanbul Medeniyet University, Türkiye
Hatice Deniz Gur
Columbia University, Amerika Birleşik Devletleri
Mevlana Derya Balbay
T.C. Sağlık Bakanlığı, Türkiye
Serkan Senol
Istanbul Medeniyet University, Türkiye
Ahmet Oguz Ozkanli
Memorial Healthcare Group, Türkiye
Erdal Alkan
T.C. Sağlık Bakanlığı, Türkiye
Tulay Zenginkinet
İstanbul Medeniyet Üniversitesi, Türkiye
Prof. Dr. Abdullah AYDIN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Turhan Caskurlu
İstanbul Medeniyet Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | Turkish Journal of Medical Sciences | ||
| Dergi ISSN | 1300-0144 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2014 |
| Cilt / Sayı / Sayfa | 44 / 3 / 397–403 | DOI | 10.3906/sag-1303-128 |
| Makale Linki | https://doi.org/10.3906/sag-1303-128 | ||
| Özet |
| To evaluate the relation between biochemical recurrence (BCR) of prostate cancer and the extent of positive surgical margins (PSMs), Gleason score (GS) of the tumor at the margins, and preoperative prostate-specific antigen (PSA) levels. A total of 94 patients who underwent radical prostatectomy were recruited for this study and received postoperative follow-up care for 2 years. All specimens were evaluated for surgical margin status, PSM length, GS at positive margin, size of tumor, multifocality, invasion of seminal vesicle, lymphovascular invasion, and perineural invasion. PSM was defined as a prostate tumor. Out of 94 patients, 34 patients (36.2%) had PSMs and 46 patients (48.9%) had BCR. A statistically significant relation between having a high risk of BCR of prostate cancer and having high preoperative PSA levels (P < 0.001), PSMs (P < 0.001), or a high GS at the surgical margin (P = 0.024) was found. High preoperative PSA levels, PSMs, and tumors with high GS at the margins have a poor prognostic impact, and they correlate with a higher rate of BCR. Close follow-up of patients with PSMs with high GS and high levels of preoperative PSA is recommended. |
| Anahtar Kelimeler |
| Prostate cancer | surgical margin | biochemical recurrence |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| TRDizin | 3 |