Gastric Adenocarcinoma Biomarker Expression Profiles and their Prognostic Value
Yazarlar (9)
Serkan Senol
Istanbul Goztepe Training & Research Hospital, Türkiye
Prof. Dr. Abdullah AYDIN
Kırşehir Ahi Evran Üniversitesi, Türkiye
Duygu Kosemetin
Van Res & Training Dist Hosp, Türkiye
Dilek Ece
Istanbul Kartal Dr Lutfi Kirdar Training & Research Hospital, Türkiye
Ibrahim Akalin
Istanbul Medeniyet University, Türkiye
Hasan Abuoglu
Istanbul Haydarpasa Numune Training & Research Hospital, Türkiye
Esra Akdeniz Duran
Istanbul Medeniyet University, Türkiye
Dincer Aydin
Istanbul Kartal Dr Lutfi Kirdar Training & Research Hospital, Türkiye
Burcak Erkol
Istanbul Haydarpasa Numune Training & Research Hospital, Türkiye
| Makale Türü | Özgün Makale (ESCI dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY | ||
| Dergi ISSN | 0731-8898 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Cilt / Sayı / Sayfa | 35 / 3 / 206–221 | DOI | 10.1615/JEnvironPatholToxicolOncol.2016016099 |
| Özet |
| Expression levels of several molecules implicated in carcinogenesis were examined by immunohistochemical staining, and the prognostic significance of their expression levels in gastric adenocarcinoma (GA) was evaluated. A total of 115 GA and 20 control gastric tissue samples were evaluated by immunohistochemistry using 33 antibodies targeting molecules known to play a part in the development of various tumors. Overexpression of carbonic anhydrase IX (CAIX) and loss of AT-rich interactive domain-containing protein 1A (ARID1A), aldehyde dehydrogenase 1 (ALDH1), and CD44 expression in GA patients were significantly correlated with lymph node (LN) metastasis, advanced tumor stage, and poor prognosis. The results demonstrated that ALDH1A and ARID1A may be strong independent prognostic factors associated with overall survival and recurrence-free survival (p < 0.01 and p < 0.05, respectively). Our results demonstrated that ALDH1, CD44, ARID1A, and CAIX in immunoreactive GA tumor cells exhibit different expression profiles compared with control cells and that these differences are associated with patient survival. The molecules with differential expression profiles were associated with some common functions, including hypoxia, epithelial-to-mesenchymal transition, and SW1/SNF-mediated chromatin remodeling. In addition, the loss of ALDH1, ARID1A, and CD44 and the overexpression of CAIX are important for tumor invasion and metastasis; therefore, they may serve as useful prognostic indicators of long-term survival in patients with GA. In conclusion, our study found that abnormal expression of some of the proteins evaluated in GA tumor cells might have an important role in carcinogenesis and tumor progression and thus may influence the prognosis of patients with GA. |
| Anahtar Kelimeler |
| gastric adenocarcinoma | tumor pathway molecules | immunohistochemistry | prognostic factors |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |