Stromal Clues in Endometrial Carcinoma: Loss of Expression of β-Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptor
Yazarlar (9)
Serkan Senol
Istanbul Medeniyet University, Türkiye
Ilyas Sayar
Erzincan Binali Yildirim University, Türkiye
Ayse B. Ceyran
Istanbul Medeniyet University, Türkiye
Ibrahim Ibiloglu
Dicle University, Türkiye
Ibrahim Akalin
Yuzuncu Yil University, Türkiye
Ugur Firat
Dicle University, Türkiye
Duygu Kosemetin
Res & Training Dist Hosp, Türkiye
Pinar Engin Zerk
Istanbul Medeniyet University, Türkiye
Prof. Dr. Abdullah AYDIN
Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | ||
| Dergi ISSN | 0277-1691 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2016 |
| Cilt / Sayı / Sayfa | 35 / 3 / 238–248 | DOI | 10.1097/PGP.0000000000000233 |
| Makale Linki | https://doi.org/10.1097/pgp.0000000000000233 | ||
| Özet |
| Epithelial-stroma interactions in the endometrium are known to be responsible for physiological functions and emergence of several pathologic lesions. Periglandular stromal cells act on endometrial cells in a paracrine manner through sex hormones. In this study, we immunohistochemically evaluated the expression of epithelial-mesenchymal transition regulators (SNAIL/SLUG, TWIST, ZEB1), adhesion molecules (β-catenin and E-cadhenin), estrogen (ER)-progesterone (PR) receptor and their correlation with each other in 30 benign, 148 hyperplastic (EH), and 101 endometrioid-type endometrial carcinoma (EC) endometria. In the epithelial component, loss of expression in E-cadherin, ER and PR, and overexpression of TWIST and ZEB1 were significantly higher in EC than in EH (P<0.01). In the periglandular stromal component, β-catenin and SNAIL/SLUG expression were significantly higher in normal endometrium and simple without atypical EH compared with complex atypical EH and EC (P<0.01). In addition, periglandular stromal TWIST expression was significantly higher in EH group compared with EC (P<0.05). There was significantly negative correlation between β-catenin and ER, TWIST and ER, and TWIST and PR in hyperplastic and carcinomatous glandular epithelium, whereas there was a significantly positive correlation between β-catenin and SNAIL-SLUG, β-catenin and TWIST, β-catenin and ER, β-catenin and PR, SNAIL-SLUG and ER, SNAIL-SLUG and PR, TWIST and ER, TWIST and PR, in periglandular/cancer-associated stromal cells (P<0.01). In conclusion, the pattern of positive and negative correlations in the expression of epithelial-mesenchymal transition regulators (SNAIL-SLUG and TWIST), sex hormone receptors (ER and PR), and β-catenin between ECs and hyperplasia, as well as between epithelium and stroma herein, is suggestive of a significant role for these proteins and their underlying molecular processes in the development of endometrial carcinomas. |
| Anahtar Kelimeler |
| Endometrium | EMT | beta-Catenin | E-cadherin | Sex steroid receptors |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |