| Yazarlar (9) |
Serkan Senol
Istanbul Medeniyet University, Türkiye |
|
Ilyas Sayar
Erzincan Binali Yildirim University, Türkiye |
|
Ayse B. Ceyran
Istanbul Medeniyet University, Türkiye |
|
Ibrahim Ibiloglu
Dicle University, Türkiye |
|
Ibrahim Akalin
Yuzuncu Yil University, Türkiye |
|
Ugur Firat
Dicle University, Türkiye |
|
Duygu Kosemetin
Res & Training Dist Hosp, Türkiye |
|
Pinar Engin Zerk
Istanbul Medeniyet University, Türkiye |
Prof. Dr. Abdullah AYDIN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
| Özet |
| Epithelial-stroma interactions in the endometrium are known to be responsible for physiological functions and emergence of several pathologic lesions. Periglandular stromal cells act on endometrial cells in a paracrine manner through sex hormones. In this study, we immunohistochemically evaluated the expression of epithelial-mesenchymal transition regulators (SNAIL/SLUG, TWIST, ZEB1), adhesion molecules (β-catenin and E-cadhenin), estrogen (ER)-progesterone (PR) receptor and their correlation with each other in 30 benign, 148 hyperplastic (EH), and 101 endometrioid-type endometrial carcinoma (EC) endometria. In the epithelial component, loss of expression in E-cadherin, ER and PR, and overexpression of TWIST and ZEB1 were significantly higher in EC than in EH (P<0.01). In the periglandular stromal component, β-catenin and SNAIL/SLUG expression were significantly higher in normal endometrium and simple without atypical EH compared with complex atypical EH and EC (P<0.01). In addition, periglandular stromal TWIST expression was significantly higher in EH group compared with EC (P<0.05). There was significantly negative correlation between β-catenin and ER, TWIST and ER, and TWIST and PR in hyperplastic and carcinomatous glandular epithelium, whereas there was a significantly positive correlation between β-catenin and SNAIL-SLUG, β-catenin and TWIST, β-catenin and ER, β-catenin and PR, SNAIL-SLUG and ER, SNAIL-SLUG and PR, TWIST and ER, TWIST and PR, in periglandular/cancer-associated stromal cells (P<0.01). In conclusion, the pattern of positive and negative correlations in the expression of epithelial-mesenchymal transition regulators (SNAIL-SLUG and TWIST), sex hormone receptors (ER and PR), and β-catenin between ECs and hyperplasia, as well as between epithelium and stroma herein, is suggestive of a significant role for these proteins and their underlying molecular processes in the development of endometrial carcinomas. |
| Anahtar Kelimeler |
| Endometrium | EMT | beta-Catenin | E-cadherin | Sex steroid receptors |
| Makale Türü |
Özgün Makale
|
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY |
| Dergi ISSN | 0277-1691 Wos Dergi Scopus Dergi |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2016 |
| Cilt No | 35 |
| Sayı | 3 |
| Sayfalar | 238 / 248 |
| DOI Numarası | 10.1097/PGP.0000000000000233 |
| Makale Linki | https://doi.org/10.1097/pgp.0000000000000233 |
| Atıf Sayıları | |
| WoS | 18 |
