Comparison of hyaluronate/carboxymethylcellulose membrane and melatonin for prevention of adhesion formation in a rat model
Yazarlar (6)
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | HUMAN REPRODUCTION | ||
| Dergi ISSN | 0268-1161 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2005 |
| Cilt / Sayı / Sayfa | 20 / 7 / 2021–2024 | DOI | 10.1093/humrep/deh846 |
| Makale Linki | https://academic.oup.com/humrep/article-pdf/20/7/2021/6952890/deh846.pdf | ||
| Özet |
| To investigate the effectiveness of melatonin in preventing post-operative adhesion formation and to compare it with the efficacy of hyaluronate/carboxymethylcellulose membrane in a rat model. Following pilot studies, 35 rats were operated on in the full study. In 15 animals (group one), 10 standard lesions were inflicted in each uterine horn (total 30 horns) and melatonin was applied before closure of the abdomen. In the second group, 20 animals were operated on and one of the uterine horns (total 20 horns) with standard lesions was treated with hyaluronate/carboxymethylcellulose membrane and the other uterine horn served as a control. Second-look operations were performed 1 week later and adhesion scores were compared. The adhesion scores of uterine horns treated with melatonin and of uterine horns treated with hyaluronate/carboxymethylcellulose membrane were significantly lower than the scores of the controls (P < 0.001). There was no statistically significant difference between the adhesion scores of uterine horns treated with melatonin and of uterine horns treated with hyaluronate/carboxymethylcellulose membrane (P > 0.05). Both melatonin and hyaluronate/carboxymethylcellulose membrane were effective in prevention of adhesion formation in a rat uterine horn model. |
| Anahtar Kelimeler |
| adhesion formation | hyaluronate-carboxymethyl cellulose membrane | melatonin | surgical barriers | rat uterine horn model |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| WoS | 27 |