img
img
The effects of exogenous interleukin-4 on hypoxia-induced lung injury   
Yazarlar (4)
H Ozturk
Prof. Dr. Hülya ÖZTÜRK Prof. Dr. Hülya ÖZTÜRK
Kırşehir Ahi Evran Üniversitesi, Türkiye
H Buyukbayram
MC Tuncer
Devamını Göster
Özet
The aim of this study was to determine the effects of recombinant human interleukin-4 (rhIL-4) on hypoxia-induced lung injury in immature rats. The study was performed on 1-day-old Sprague Dawley rat pups. Group 1 (n = 7) served as nonhypoxic controls. Group 2 (untreated, n = 7) rats were subjected to hypoxia-reoxygenation (H/O) and were then returned to their mothers. Group 3 (rhIL-4 treated, n = 7) rats were subjected to H/O, were returned to their mothers, and were treated with rhIL-4 (75 microg/kg subcutaneously) for the next 3 days. All animals were killed on day 4 and lung specimens were obtained to determine the tissue level of malondialdehyde (MDA) and histological changes. In the untreated group, MDA levels were significantly increased compared to control and rhIL-4 groups. In the rhIL-4 treated group, MDA levels were not significantly different compared to control group. The rhIL-4 treated group had a significantly lower score of pathological lesions and alveolar hemorrhage grade values than the untreated group. The untreated animals had areas marked intraalveolar hemorrhage, capillary congestion, interstitial edema, and hypercellularity of lung that were not seen in the rhIL-4 treated rats. In conclusion, this study found beneficial effects of rhIL-4 in an experimental model on the hypoxia-induced lung injury.
Anahtar Kelimeler
lung | ischemia-reperfusion injury | cytokine | interleukin-4
Makale Türü Özgün Makale
Makale Alt Türü ESCI dergilerinde yayımlanan tam makale
Dergi Adı PEDIATRIC SURGERY INTERNATIONAL
Dergi ISSN 0179-0358 Wos Dergi Scopus Dergi
Makale Dili İngilizce
Basım Tarihi 02-2006
Cilt No 22
Sayı 2
Sayfalar 197 / 201
Doi Numarası 10.1007/s00383-006-1635-6
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
WoS 2
The effects of exogenous interleukin-4 on hypoxia-induced lung injury

Paylaş