Serum neurofilament light chain as a potential biomarker in restless legs syndrome: a cross-sectional study
Yazarlar (5)
Dr. Öğr. Üyesi Aysu YETİŞ Kırşehir Ahi Evran Üniversitesi, Türkiye
Asuman Çelikbilek Kırşehir Ahi Evran Üniversitesi, Türkiye
Doç. Dr. Bilal İLANBEY Kırşehir Ahi Evran Üniversitesi, Türkiye
Naime Meriç Konar Bandırma Onyedi Eylül Üniversitesi, Türkiye
Dr. Öğr. Üyesi Selcen DURAN Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | NEUROLOGICAL RESEARCH (Q4) | ||
| Dergi ISSN | 0161-6412 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2025 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 47 / 4 / 284–289 | DOI | 10.1080/01616412.2025.2472836 |
| Makale Linki | https://doi.org/10.1080/01616412.2025.2472836 | ||
| Özet |
| ObjectiveNeurofilament light chain (NfL) has emerged as a promising biomarker for several neurological diseases. Therefore, we investigated its serum levels and their association with disease characteristics, including duration, severity, and medication use in patients with restless legs syndrome (RLS).MethodThis cross-sectional prospective study included 71 RLS patients and 70 healthy controls. RLS patients were characterized based on disease duration, severity, and medication use. NfL levels were quantified using commercial enzyme-linked immunosorbent assay kits.ResultNo significant differences in NfL levels were observed between RLS patients and controls (p > 0.05). Furthermore, the levels were not significantly associated with disease duration or severity in RLS patients (p > 0.05).ConclusionThese findings do not support the use of NfL as a biomarker for RLS. Further large-scale studies are … |
| Anahtar Kelimeler |
| Neurofilament light chain | restless legs syndrome | neurodegeneration | Willis-Ekbom disease | biomarker |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 2 |
| Web of Science | 2 |