| Yazarlar (5) |
Hüseyin Akşit
Erzincan Binali Yıldırım Üniversitesi, Turkey |
|
Samed Şimşek
Erzincan Binali Yıldırım Üniversitesi, Turkey |
|
Ali Aydın
Bozok Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Yusuf BAYAR
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Mustafa Alkan
Bozok Üniversitesi, Türkiye |
| Özet |
| The essential oil extracted from the aerial parts of Ferulago setifolia K. Koch was analysed using GC/MS, revealing 33 compounds, with 2,3,4-trimethyl benzaldehyde (41.24%), α-pinene (21.58%) and sabinene (10.46%) as major constituents. The biological activity profile of essential oils, including antifungal, insecticidal and antiproliferative activities, was documented for the first time. The oil demonstrated significant antifungal activity, completely inhibiting the growth of Verticillium dahliae at higher doses and showing dose-dependent inhibition against Alternaria solani. It also exhibited moderate insecticidal activity against Rhyzopertha dominica and Tribolium confusum, achieving a mortality rate of up to 49.3% after 48 h at a 5% concentration. Furthermore, the essential oil showed potent antiproliferative effects against a wide range of cancer cell lines, including lung (Calu1), breast (MCF7), colon (HT29) and gynaecological (HeLa) cancers, while maintaining low cytotoxicity on normal cell lines (MRC5, FL). The IC50 values ranged from 8.13 μg/mL (A2780) to 92.88 μg/mL (HT29), with notable results such as 22.84 μg/mL for Calu1 and 58.26 μg/mL for MCF7. Compared to the standard anticancer drug 5-fluorouracil, the essential oil exhibited superior or comparable activity against certain cancer cell lines. The results showed that essential oils have specificity against cancer cell lines. These findings suggest that the essential oil of F. setifolia holds potential as a natural source for antifungal, insecticidal and antiproliferative agents. The results contribute significantly to the pharmacological and agricultural potential of this species. |
| Anahtar Kelimeler |
| antiproliferation | bioactive aldehydes | biological activity | cytotoxicity | essential oil | Ferulago setifolia |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Flavour and Fragrance Journal |
| Dergi ISSN | 0882-5734 Wos Dergi Scopus Dergi |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2025 |
| Sayı | 1 |
| Doi Numarası | 10.1002/ffj.3859 |
| Atıf Sayıları |
