A comprehensive investigation of Schiff bases and bis-α-aminophosphonates as potent agents against Alzheimers disease by computer-aided drug discovery techniques and in vitro examinations
Yazarlar (5)
Emel Ekinci Çankırı Karatekin Üniversitesi, Türkiye
Prof. Dr. Harun ÇİFTÇİ Kırşehir Ahi Evran Üniversitesi, Türkiye
Şevki Adem Çankırı Karatekin Üniversitesi, Türkiye
Doç. Dr. Özlem GÜNDOĞDU AYTAÇ Kırşehir Ahi Evran Üniversitesi, Türkiye
Volkan Eyüpoğlu Çankırı Karatekin Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q2) | ||
| Dergi ISSN | 0022-2860 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2025 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 1333 / 1 / 141734–0 | DOI | 10.1016/j.molstruc.2025.141734 |
| Makale Linki | https://doi.org/10.1016/j.molstruc.2025.141734 | ||
| Özet |
| In this study, we designed and synthesized new Schiff bases (7–11) and bis-α-aminophosphonate derivatives (13–16) to examine their inhibitory properties against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes which are associated with Alzheimer's disease (AD). All newly synthesized compounds were characterized by FT-IR, 1H, and 13C NMR and were tested were appraised for their inhibitory potential opposite to AChE and BChE enzymes, by determining their IC50 and Ki values. Bis-α-aminophosphonate derivatives showed significantly strong inhibitory affinity against AChE, whereas they had weak inhibitory activities against BChE. Schiff bases exhibited low inhibitory activity against both AChE and BChE. Among bis-α-aminophosphonates, compounds 14, 15, and 16 showed excellent inhibitory properties against AChE with an IC50 value of 6.48, 9.00, and 10.88 μM, respectively … |
| Anahtar Kelimeler |
| Alzheimer's disease | Cholinesterase | DFT | Enzyme inhibition | Molecular docking | Molecular dynamics |
Science Direct
A comprehensive investigation of Schiff bases and bis-α-aminophosphonates as potent agents against Alzheimers disease by computer-aided drug discovery techniques and in vitro examinations
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 5 |
| Scopus | 4 |
| Web of Science | 3 |