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The immunomodulator effect of Stevia rebaudiana Bertoni mediated by TNF‐α and IL‐1β in peripheral blood in diabetic rats     
Yazarlar (4)
Erhan Cebeci
İstanbul Beykent Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ertan KATIRCI Dr. Öğr. Üyesi Ertan KATIRCI
Türkiye
Mustafa Karhan
Türkiye
Emin Türkay Korgun
Akdeniz Üniversitesi, Türkiye
Devamını Göster
Özet
Bertoni, which is a medicinal plant used in the treatment of diabetes, was the focus of this study aiming to investigate its immunomodulatory properties in diabetes. To form the diabetes group, rats were injected intraperitoneally with STZ and rats with blood glucose levels above 200 mg/dL 2 days after STZ injection were included in the diabetes group. To form the stevia and diabetes + stevia groups, stevia was administered daily by gavage to both healthy and diabetic rats for 28 days. At the end of 28 days, the levels of interleukin-1 beta and tumor necrosis factor-alpha in the blood were measured by ELISA. CD3, CD4, and CD8 protein levels in the blood were determined by flow cytometry. Rat body weight increased in the diabetes +25 mg/kg bW stevia group compared with the diabetes group. Blood glucose levels were significantly decreased in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (** < .01). IL-1β cytokine levels decreased significantly in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (** < .01). TNF-α cytokine levels decreased significantly in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (** < .01). The amount of CD8 + T cells decreased significantly in the diabetes +25 mg/kg bW stevia group compared to the diabetes group (* < .05). The stevia diet leads to a reduction in peripheral circulating cytotoxic T cells and proinflammatory cytokines interleukin-1 beta and tumor necrosis factor-alpha under hyperglycemic conditions.
Anahtar Kelimeler
Asteraceae | cytokine | diabetes | lymphocyte | Stevia rebaudiana Bertoni
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Food Science &amp; Nutrition
Dergi ISSN 2048-7177 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q2
Makale Dili Türkçe
Basım Tarihi 07-2024
Cilt No 12
Sayı 10
Sayfalar 7581 / 7590
Doi Numarası 10.1002/fsn3.4371
Makale Linki http://dx.doi.org/10.1002/fsn3.4371