| Yazarlar (15) |
Emine Alarcin
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Zeynep Puren Akguner
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Ayca Bal Ozturk
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Gokcen Yasayan
|
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Esra Ilhan-Ayisigi
|
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Aslihan Kazan
|
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Ozlem Yesil-Celiktas
|
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Dila Sener Akcora
|
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Dilek Akakin
|
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Banu Kocaaga
|
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Gamze Eren
|
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Kasım Gunes
|
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Oya Kerimoglu
|
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Hatice Kubra Seki
|
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F Seniha Guner
|
| Özet |
| The effective treatment of critical-sized bone defects requires a coordinated interaction between osteogenesis and angiogenesis. Inspired by natural bone tissue, we developed a bilayer vascularized bone construct using extrusion-based dual 3D bioprinting. The construct consists of two layers: a bone-mimetic layer, which includes highly methacrylated gelatin (GelMAHIGH), hyaluronic acid, alginate, osteoblast cells, and bone morphogenetic protein-2 (BMP-2) loaded polylactic-co-glycolic acid (PLGA) nanoparticles; and a vessel-mimetic layer, composed of low methacrylated gelatin (GelMALOW), alginate, endothelial cells, and vascular endothelial growth factor (VEGF)-loaded PLGA nanoparticles. These layers were designed to form hierarchical microstructures that enable sustained release of growth factor (GF) thereby stimulating both osteogenic and angiogenic processes. The nanoparticles were synthesized ... |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | International Journal of Biological Macromolecules |
| Dergi ISSN | 1879-0003 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCIExp |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2025 |
| Sayfalar | 141440 / 0 |
