| Yazarlar (5) |
Aykut Özkul
Ankara Üniversitesi, Türkiye |
|
Koray Ergünay
Türkiye |
Dr. Öğr. Üyesi Aydan KÖYSÜREN
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
Feray Alkan
Ankara Üniversitesi, Türkiye |
|
Ethem Murat Arsava
Hacettepe Üniversitesi, Türkiye |
| Özet |
| West Nile fever is an important zoonotic infection caused by West Nile virus (WNV), a member of the Flaviviridae. Previous serological data from Turkey suggest widespread WNV circulation. This report includes cases of human and equine WNV infections occurring concurrently, and manifesting as central nervous system infections, in two neighboring provinces of Central Anatolia, Turkey. A partial phylogenetic analysis of the causative virus is given for the first time. The cases were reported in February (horses) and March (human). Symptoms of the disease were similar in the two species, characterized by neurological manifestations suggesting meningoencephalitis. Real-time/nested PCRs and commercial immunoassays and a plaque reduction neutralization assay were employed for the detection of viral RNA and specific antibodies, respectively. WNV RNAs were detected in buffy coat (horses) and cerebrospinal fluid (human) samples. Partial nucleotide sequences of the E-gene coding region revealed that the strains are closely related to viruses of lineage 1, clade 1a. Accompanying equine serosurveillance demonstrated WNV-specific antibodies in 31.6% of the samples. This is the first report of acute WNV infections caused by lineage 1 strains from Turkey, in concordance with previous reports from some European and North African countries. |
| Anahtar Kelimeler |
| West Nile virus | WNV | Encephalitis | Molecular epidemiology | Central Anatolia | Turkey |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | International Journal of Infectious Diseases |
| Dergi ISSN | 1201-9712 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2013 |
| Cilt No | 17 |
| Sayı | 7 |
| Sayfalar | 546 / 551 |
| Doi Numarası | 10.1016/j.ijid.2013.02.005 |
| Makale Linki | https://doi.org/10.1016/j.ijid.2013.02.005 |
| Atıf Sayıları | |
| WoS | 33 |
| SCOPUS | 39 |
| Google Scholar | 64 |
