Relationship between systemic inflammation indices and time of symptom onset in cardiac remodeling after first ST-segment elevation myocardial infarction
Yazarlar (2)
Ahmet Kıvrak Türkiye
Dr. Öğr. Üyesi Alp YILDIRIM Kırşehir Ahi Evran Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Kardiologia Polska (Q1) | ||
| Dergi ISSN | 0022-9032 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 10-2023 |
| Kabul Tarihi | 12-04-2026 | Yayınlanma Tarihi | – |
| Cilt / Sayı / Sayfa | 81 / 9 / – | DOI | 10.33963/KP.a2023.0150 |
| Makale Linki | https://doi.org/10.33963/kp.a2023.0150 | ||
| Özet |
| Background: Circadian variations play a pivotal role in both leukocyte trafficking and inflammatory response. This may affect the course of cardiac healing after myocardial infarction (MI).Aims: The present study investigated the relationship between the systemic immune inflammation (SII) index and the systemic inflammation response index (SIRI), two new inflammation indices integrating white blood cell subsets and platelets, and the time of onset of symptoms in left ventricular adverse remodeling (LVAR) after ST-segment elevation MI (STEMI).Methods: In this retrospective study, we included 51 2 patients with first-time STEMI. The time of onset of symptoms was divided into 4 intervals: 06: 00–11: 59, 12: 00–17: 59, 18: 00–23: 59, and 00: 00–05: 5 9. The endpoint was LVAR, defined as an increase in left ventricular end-diastolic and end-systolic volume by≥ 12% at 6 m onth s.Results: The time of onset of chest pain most often occurred between 06: 0 0 and 11: 5 9 AM. In this window of time, median SII and SIRI indices were higher than in other time interval s. An increased SIRI level (odds ratio [OR], 3.03; P< 0.001), symptom onset in the morning hours (OR, 2.92; P= 0.03), and an increased Global Registry of Acute Coronary Events (GRACE) score (OR, 1.16; P< 0.001) were determined as independent predictors of LVAR. The threshold value of the SIRI to discriminate between patients with and without LVAR was> 2. 5 (area under the curve [AUC], 0.84; P< 0.001). The SIRI showed superior diagnostic performance compared to the SII index.Conclusions: In STEMI patients, an increased SIRI was independently associated with LVAR. This was … |
| Anahtar Kelimeler |
| biomarker | cardiac remodeling | inflammation | myocardial infarction |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 12 |