Novel substituted benzothiazole and Imidazo [2, 1-b][1, 3, 4] Thiadiazole derivatives: Synthesis, characterization, molecular docking study, and investigation of their in vitro ...
Yazarlar (5)
Mustafa Er
Arif Özer
Şahin Direkel
Tuncay Karakurt
Hakan Tahtaci
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q3) | ||
| Dergi Tarandığı Indeksler | |||
| Makale Dili | İngilizce | Basım Tarihi | 10-2019 |
| Cilt / Sayı / Sayfa | 1194 / 0 / 284–296 | DOI | – |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0022286019306763 | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| In this study, we synthesized new imidazo[2,1-b][1,3,4]thiadiazole derivatives containing benzothiazole group. To this end, we firstly obtained the benzo[d]thiazol-2-ylthio/oxy acetonitrile compounds (3a,b), the starting materials, in high yields (82% and 87%, respectively). Then, we synthesized the 2-amino-1, 3,4-thiadiazole derivatives (4a,b) from the reaction of these nitrile derivatives (3a,b) with thiosemicarbazide in trifluoroacetic acid (TFA) (in yields of 83% and 84%). Finally, we synthesized the imidazo[2,1-b][1,3,4]thiadiazole derivatives (5-24) containing benzothiazole group, which are the target compounds, from reactions of 2-amino-1,3,4-thiadiazole derivatives (4a,b) with phenacyl bromide derivatives (in yields of 53%–73%).All of the compounds synthesized were characterized with 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectroscopy.Antileishmanial and antibacterial activity tests were … |
| Anahtar Kelimeler |
