| Yazarlar (5) |
Mustafa Er
|
|
Arif Özer
|
|
Şahin Direkel
|
|
Tuncay Karakurt
|
|
Hakan Tahtaci
|
| Özet |
| In this study, we synthesized new imidazo[2,1-b][1,3,4]thiadiazole derivatives containing benzothiazole group. To this end, we firstly obtained the benzo[d]thiazol-2-ylthio/oxy acetonitrile compounds (3a,b), the starting materials, in high yields (82% and 87%, respectively). Then, we synthesized the 2-amino-1, 3,4-thiadiazole derivatives (4a,b) from the reaction of these nitrile derivatives (3a,b) with thiosemicarbazide in trifluoroacetic acid (TFA) (in yields of 83% and 84%). Finally, we synthesized the imidazo[2,1-b][1,3,4]thiadiazole derivatives (5-24) containing benzothiazole group, which are the target compounds, from reactions of 2-amino-1,3,4-thiadiazole derivatives (4a,b) with phenacyl bromide derivatives (in yields of 53%--73%).All of the compounds synthesized were characterized with 1H NMR, 13C NMR, FT-IR, elemental analysis, and mass spectroscopy.Antileishmanial and antibacterial activity tests were ... |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Molecular Structure |
| Dergi Tarandığı Indeksler | |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2019 |
| Cilt No | 1194 |
| Sayfalar | 284 / 296 |
