| Yazarlar |
A. Duran
|
Prof. Dr. Hülya ÖZTÜRK
Kırşehir Ahi Evran Üniversitesi, Türkiye |
|
E. H. Terzi
|
|
M. Tosun
|
|
H. Ozturk
|
|
T. Ocak
|
|
A. Kukner
|
| Özet |
| Objective : Ischemia-reperfusion (I-R) injury of the intestine is a significant problem because the initial damage caused by ischemia is exacerbated by reperfusion. In this study, we examined the protective effect of montelukast against I-R-induced intestinal tissue damage. Materials and methods : Eight-week-old male Sprague-Dawley rats were randomly divided into three treatment groups : a sham-operated group, a group receiving I-R, and a group receiving I-R plus montelukast (I-R/M). Tissue samples were evaluated and scored histologically. The blood levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), and cardiotrophin-1 (CT-1) were measured. Results : In the I-R group, the histological score and the levels of serum MDA and MPO were increased compared with those in the control group. In the I-R/M group, the histological score and serum MDA and MPO levels were significantly decreased compared with those in the I-R group. Additionally, compared with the IR group, the I-R/M group had increased serum GSH and CT-1 levels and a decreased intestinal injury score. Ileal sections from the I-R/M group showed minimal alterations, characterized by moderate lifting of the epithelial layer from the lamina propria, and few apoptotic enterocytes were observed compare with the number in the I-R group. Conclusion : The findings of the present study demonstrated that montelukast can protect I-R-induced intestinal damage in rats. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ACTA CHIRURGICA BELGICA |
| Dergi ISSN | 0001-5458 |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2013 |
| Cilt No | 113 |
| Sayı | 6 |
| Sayfalar | 401 / 405 |
